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PTEN — TGFB1
Text-mined interactions from Literome
Ebert et al., Br J Cancer 2002
(Pancreatic Neoplasms) :
Recently, it has been demonstrated that
PTEN expression is
regulated by
TGF-beta1 ... In addition, in the pancreas of TGF-beta1 transgenic mice the expression of PTEN was significantly reduced ( P < 0.01 ), as compared to wildtype littermates and incubation of PANC-1 cells with TGF-beta1 decreased PTEN mRNA levels after 24 h. Inasmuch as TGF-beta1 decreases PTEN expression in human pancreatic cancer cells and human pancreatic cancers overexpress TGF-beta1, the reduced expression of
PTEN in pancreatic cancer may be
mediated by
TGF-beta1 overexpression
Chow et al., Carcinogenesis 2007
(Pancreatic Neoplasms) :
Phosphatase and tensin homolog deleted on chromosome 10 ( PTEN ) is rarely mutated in pancreatic cancers, but its regulation by
transforming growth factor ( TGF ) -beta might
mediate growth suppression and other oncogenic actions
Yang et al., J Cell Biochem 2009
(Carcinoma, Hepatocellular...) :
Previous studies have showed that
PTEN mRNA expression is
down-regulated by
TGF-beta1 in various cell lines ... Based on the PTEN promoter dual-luciferase report assay, we have found that
PTEN transcription is not
affected by
TGF-beta1 ... What interested us was that transfection of PTEN coding sequence increased TGF-beta1 induced degradation of PTEN mRNA, suggesting that PTEN coding region was account for
TGF-beta1 mediated down-regulation of
PTEN ... In addition,
TGF-beta1 down-regulated
PTEN expression was blocked by the TbetaIR inhibitor SB431542 and the p38 inhibitor SB203580, suggesting Smad and p38 MAPK signal pathways played crucial roles in PTEN down-regulation via TGF-beta1 stimulation ... Collectively, our data clearly demonstrated that
TGF-beta1 mediated down-regulation of
PTEN was post-transcriptional and post-translational, depending on its coding sequence, Smad and p38-MAPK signal pathways were involved in this down-regulation