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ATF4 — STAT3
Text-mined interactions from Literome
Chen et al., Diabetologia 2012
(Diabetes Mellitus, Type 1...) :
Furthermore, knockdown of the Stat3 gene or inhibiting
STAT3 activity restored ER homeostasis in cells exposed to high glucose and
prevented ATF4 activation, suggesting that STAT3 is required for high-glucose induced ER stress
Lu et al., J Dermatol 2013
:
Importantly, JUN may
regulate activating transcription factor 3 expression to involve cell proliferation process ; STAT1 and
STAT3 can inhibit tissue inhibitor of metalloproteinases-3 expression to modulate the cell adhesion molecule pathway ; NF-?B and E2F1 can downregulate cyclin D1, but upregulate proliferating cell nuclear antigen expression to promote the cell cycle pathway