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BDNF — HCLS1
Text-mined interactions from Literome
Woo et al., Nat Neurosci 2005
(Synaptic Transmission) :
Activation of
p75NTR by
proBDNF facilitates hippocampal long-term depression ... p75 ( NTR-/- ) mice also showed a decrease in the expression of NR2B, an NMDA receptor subunit uniquely involved in LTD.
Activation of
p75 ( NTR ) by
proBDNF enhanced NR2B dependent LTD and NR2B mediated synaptic currents
Bamji et al., J Cell Biol 1998
:
When sympathetic neuron survival is maintained with low quantities of NGF or KCl, the neurotrophin brain derived neurotrophic factor (BDNF), which does not activate Trk receptors on sympathetic neurons, causes neuronal apoptosis and increased phosphorylation of c-jun. Function blocking antibody studies indicate that this apoptosis is due to
BDNF mediated activation of
p75NTR