Reijerkerk et al., J Immunol 2008
(Encephalomyelitis, Autoimmune, Experimental) :
Importantly, live imaging and immunoblot analyses of rat brain endothelial cells revealed that tPA and ERK1/2 control the breakdown of the tight junction protein occludin Kaur et al., J Cereb Blood Flow Metab 2011
(Brain Ischemia...) :
Both tPA and age independently increased claudin 5 and occludin phosphorylation during ischemia
Mishiro et al., Neuroscience 2012
(Cerebral Hemorrhage...) :
GM6001 significantly reduced tPA elevated brain hemoglobin, MMP-9, and inhibited the degradation of occludin and ZO-1 induced by tPA , but not claudin-5