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MMP1 — TP53
Text-mined interactions from Literome
Sun et al., Mol Carcinog 1999
(Neoplasm Metastasis) :
p53 transcriptionally
activates expression of the genes encoding epidermal growth factor receptor,
matrix metalloproteinase (MMP)-2 , cathepsin D, and thrombospondin-1 but represses expression of the genes encoding basic fibroblast growth factor and multidrug resistance-1
Ala-aho et al., Oncogene 2002
(Carcinoma, Squamous Cell...) :
These results show, that wild-type
p53 potently
inhibits expression of MMP-13 and
MMP-1 by SCC cells independently of its pro-apoptotic effect
Sun et al., J Cell Biochem 2004
:
We also demonstrate that both p300 and TATA box binding proteins cooperated with the transcription factor AP-1 to induce the promoter of MMP1 ; however,
p53 only
inhibited the p300 mediated induction of the
MMP1 promoter and the inhibition was -72AP-1 dependent
Kim et al., Exp Dermatol 2008
:
Basal and UV-induced
MMP-1 expression are
inhibited by
p53 in human dermal fibroblasts ... However, little is known about the
role of
p53 on
MMP-1 expression in human skin ... Here, we investigated the
effects of
p53 on basal and UV-induced
MMP-1 in human dermal fibroblasts ... To verify the
role of
p53 on
MMP-1 expression, adenoviral p53 ( Ad-p53 ) gene was infected to human dermal fibroblasts ... Our results showed that basal and UV-induced
MMP-1 expression was
prevented by
Ad-p53 ... In contrast,
p53 inhibitor, pifithrin-alpha
augmented the UV-induced
MMP-1 expression ... Taken together, we suggest that
p53 inhibits basal and UV-induced
MMP-1 expression in human dermal fibroblasts
Xiao et al., J Cell Biochem 2009
(Melanoma) :
Cytoprotective effects of the lipoidic-liquiform pro-vitamin C tetra-isopalmitoyl-ascorbate ( VC-IP ) against ultraviolet-A ray induced injuries in human skin cells together with collagen retention,
MMP inhibition and
p53 gene repression
Kim et al., PloS one 2009
:
Suppression of p300 histone acetyltransferase (p300HAT) activity by the p300HAT inhibitor anacardic acid ( AA ) or by down-regulation of p300 by siRNA prevented UV-induced
MMP-1 expression and
inhibited UV-enhanced gamma-H2AX,
p53 level, and acetyl-H3
Wu et al., Cancer Res 2010
(Adenocarcinoma...) :
In addition, in lung cancer cells and xenograft tumors in nude mice, overexpression of XPC suppresses cell/tumor metastatic ability via
repression of
matrix metalloproteinase-1 (MMP1) transcription by
p53