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APOB — MTTP
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
MTTP
—
APOB
(direct interaction, two hybrid)
Bradbury et al., J Biol Chem 1999*
-
IRef Hprd Interaction:
MTTP
—
APOB
(two hybrid)
Liang et al., J Biol Chem 2001*, Bradbury et al., J Biol Chem 1999*
-
IRef Hprd Interaction:
MTTP
—
APOB
(in vivo)
Liang et al., J Biol Chem 2001*, Bradbury et al., J Biol Chem 1999*
-
IRef Ophid Interaction:
APOB
—
MTTP
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
-
IRef Ophid Interaction:
APOB
—
MTTP
(aggregation, confirmational text mining)
Bradbury et al., J Biol Chem 1999*
Text-mined interactions from Literome
Raabe et al., J Clin Invest 1999
:
We conclude that
MTP is essential for transferring the bulk of triglycerides into the lumen of the ER for VLDL assembly and is
required for the secretion of
apo B-100 from the liver
Leung et al., J Biol Chem 2000
:
Contrary to our expectations, half-normal levels of
MTP reduced the plasma
apoB100 levels to the same extent ( approximately 25-35 % ) at each level of apoB synthesis
Bakillah et al., Biochemistry 2000
:
Decreased secretion of
ApoB follows inhibition of
ApoB-MTP binding by a novel antagonist
Borradaile et al., Diabetes 2003
(Carcinoma, Hepatocellular...) :
In HepG2 human hepatoma cells, naringenin
inhibits apolipoprotein B (apoB) secretion primarily by inhibiting
microsomal triglyceride transfer protein and enhances LDL receptor (LDLr) mediated apoB containing lipoprotein uptake
Améen et al., J Biol Chem 2005
:
This effect is paralleled by a change in apoB-100 secretion, indicating that the effect of Wy on
apoB-100 secretion is
mediated by increased expression of
MTP
Cuchel et al., N Engl J Med 2007
(Hyperlipoproteinemia Type II) :
Inhibition of the
microsomal triglyceride transfer protein by BMS-201038
resulted in the reduction of
LDL cholesterol levels in patients with homozygous familial hypercholesterolemia, owing to reduced production of apolipoprotein B
Wang et al., J Biol Chem 1996
:
We studied the
role of
microsomal triglyceride transfer protein ( MTP ) in the synthesis, secretion, and cotranslational degradation of
apolipoprotein ( apo ) B using nonhepatic COS-7 cells that expressed C-terminally truncated forms of apoB ( from apoB15 to apoB94 ) with or without the large subunit of human MTP
Benoist et al., J Biol Chem 1997
:
Co-translational degradation of
apolipoprotein B100 by the proteasome is
prevented by
microsomal triglyceride transfer protein ... During the first 4 min of chase, synthesis of apoB polypeptides the size of 100-200 kDa was insensitive to the inhibitor, suggesting that inhibition of
MTP did not
affect the initiation of
apoB100 translation
Nemeth-Slany et al., Atherosclerosis 1997
:
Apo B expression is confined to the intestine and liver, and its secretion from these tissues is
dependent on the expression of a lipid transfer protein,
microsomal triglyceride transfer protein ( MTP )
Wang et al., J Biol Chem 1997
:
Secretion of
apolipoprotein B (apoB) from mammalian cells
requires the presence of functional
microsomal triglyceride transfer protein ( MTP )
van Greevenbroek et al., J Lipid Res 1998
:
This study was designed to gain insight into the
role of
microsomal triglyceride transfer protein ( MTP ) in the association of
apolipoprotein ( apo ) B with lipid during intestinal lipoprotein assembly