◀ Back to EGF
CDH1 — EGF
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
CDH1
→
EGF
(decreases)
Lu et al., Cancer Cell 2003*
Evidence: Chronic EGF treatment resulted in transcriptional downregulation of caveolin-1 and induction of the transcriptional repressor Snail, correlating with downregulation of E-cadherin expression.
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NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
EGFR/EGFR/EGF/EGF complex (EGFR-EGF)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(modification, activates)
Miravet et al., Mol Cell Biol 2003, Hoschuetzky et al., J Cell Biol 1994, Shibamoto et al., Cell adhesion and communication 1994
Evidence: assay, physical interaction
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NCI Pathway Database Stabilization and expansion of the E-cadherin adherens junction:
EGF (EGF)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(modification, collaborate)
Qian et al., EMBO J 2004, Hoschuetzky et al., J Cell Biol 1994, Takahashi et al., Exp Cell Res 1996
Evidence: assay, physical interaction
-
NCI Pathway Database Stabilization and expansion of the E-cadherin adherens junction:
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
→
EGFR/EGFR/EGF/EGF complex (EGFR-EGF)
(modification, inhibits)
Qian et al., EMBO J 2004, Hoschuetzky et al., J Cell Biol 1994, Takahashi et al., Exp Cell Res 1996
Evidence: assay, physical interaction
Text-mined interactions from Literome
Al Moustafa et al., Lung Cancer 2002
(Carcinoma...) :
In contrast,
epidermal growth factor (EGF) or heparin binding EGF-like growth factor ( HB-EGF )
induces the epithelial-like to fibroblastoid conversion of A549 and H322 cell lines, slightly reduces the expression of
E-cadherin and beta-catenin, but not alpha- and gamma-catenins, and stimulates cell motility
Ackland et al., Lab Invest 2003
(Breast Neoplasms...) :
Stimulation of PMC42-LA cells with
epidermal growth factor (EGF) leads to epithelio-mesenchymal transition-like changes including up-regulation of vimentin and down-regulation of
E-cadherin
Sheth et al., Alcohol Clin Exp Res 2004
:
EGF effectively
prevented acetaldehyde induced reorganization of actin cytoskeleton and the interaction of occludin, ZO-1,
E-cadherin , and beta-catenin with the actin cytoskeleton
Takei et al., Biotechnol Lett 2005
:
Expression of
E-cadherin was increased in round hepatocytes adhered on a high coating density of PVLA ( 100 microg/ml ), and also in flat ones adhered on a low coating density of PVLA ( 1 microg/ml ) in the
presence of
epidermal growth factor (EGF)
Wang et al., Cancer Res 2007
(Pancreatic Neoplasms) :
Membrane bound heparin binding
epidermal growth factor like growth factor
regulates E-cadherin expression in pancreatic carcinoma cells
Lo et al., Cancer Res 2007
(Breast Neoplasms...) :
EGF reduced
E-cadherin expression and increased that of mesenchymal proteins
Cowden Dahl et al., Cancer Res 2008
(Neoplasm Invasiveness...) :
Matrix metalloproteinase 9 is a mediator of
epidermal growth factor dependent
e-cadherin loss in ovarian carcinoma cells ... MMP-9 involvement in
EGF dependent down-regulation of
E-cadherin was determined by siRNA specifically directed against MMP-9
Smith et al., American journal of physiology. Renal physiology 2009
:
Quantitative RT-PCR and a luciferase reporter assay suggested that
sHB-EGF repressed transcription of
E-cadherin , and a concomitant TGF-beta independent upregulation of the E-cadherin repressor Snail-2 was observed ... Quantitative RT-PCR and a luciferase reporter assay suggested that
sHB-EGF repressed transcription of
E-cadherin , and a concomitant TGF-beta independent upregulation of the E-cadherin repressor Snail-2 was observed
Singh et al., Exp Cell Res 2009
(Carcinoma, Squamous Cell) :
EGF phosphorylated PKC-delta at Y311 and ectopic expression of the mutant Y311F
prevented PKC-delta binding to
E-cadherin and EGF induced cell scattering
Mauro et al., Breast Cancer Res Treat 2010
(Breast Neoplasms) :
Our results demonstrate that OHT and
EGF activate the
E-cadherin promoter, increase E-cadherin mRNA and protein expression and enhance homotypic aggregation of MCF7 cells
Orlichenko et al., Mol Biol Cell 2009
:
Caveolin-1 and
E-cadherin closely associated at cell borders and in internalized structures upon
stimulation with
EGF
Cheng et al., Mol Endocrinol 2010
(Ovarian Neoplasms) :
Hydrogen peroxide mediates
EGF induced down-regulation of
E-cadherin expression via p38 MAPK and snail in human ovarian cancer cells ... Although it is generally believed that reactive oxygen species play important roles in intracellular signal transduction, the role of reactive oxygen species in
EGF mediated reductions in
E-cadherin remains to be elucidated ... PEG-catalase and the p38 MAPK inhibitor SB203580 abolished
EGF induced Snail, but not Slug, expression and
E-cadherin down-regulation
Cheng et al., Oncogene 2013
(Ovarian Neoplasms) :
Egr-1 mediates
epidermal growth factor induced downregulation of
E-cadherin expression via Slug in human ovarian cancer cells ... However, the molecular mechanisms underlying the
EGF induced downregulation of
E-cadherin are not fully understood ... Moreover, depletion of Egr-1 with siRNA abolished the
EGF induced downregulation of
E-cadherin and increased cell invasion ... These results provide evidence that Egr-1 is a mediator that is involved in the
EGF induced downregulation of
E-cadherin and increased cell invasion ... These two signaling pathways contribute to the
EGF induced downregulation of
E-cadherin , which subsequently increases the invasive capability of ovarian cancer cells ... These two signaling pathways contribute to the
EGF induced downregulation of
E-cadherin , which subsequently increases the invasive capability of ovarian cancer cells
Cheng et al., J Clin Endocrinol Metab 2012
:
The
effect of
EGF on the down-regulation of
E-cadherin was abolished by small interfering RNA mediated depletion of EGFR ... Moreover, the inhibition of EGF induced ERK1/2, p38, and Akt activation by pharmacological inhibitors attenuated
EGF induced Slug expression and the down-regulation of
E-cadherin , as well as subsequent cell invasion ...
EGF induces human oviductal epithelial cell invasion through the activation of ERK1/2, p38, and Akt, the up-regulation of Slug, and the down-regulation of
E-cadherin
Cheng et al., Cancer Lett 2013
(Ovarian Neoplasms) :
Hypoxia-inducible factor 1 alpha mediates
epidermal growth factor induced down-regulation of
E-cadherin expression and cell invasion in human ovarian cancer cells ... It has been shown that
E-cadherin is
down-regulated by
epidermal growth factor receptor (EGF) stimulation, and that cells with low E-cadherin expression are more invasive ... This study demonstrates an important role for HIF-1a in mediating the
effects of
EGF on Snail, Slug and
E-cadherin expression as well as invasiveness in human ovarian cancer cells
Bourboulia et al., Oncotarget 2013
(Lung Neoplasms) :
Moreover, exogenous treatment with recombinant Ala+TIMP-2 blocked
EGF induced down-regulation of
E-cadherin
Cheng et al., Biochem Biophys Res Commun 2013
(Neoplasm Invasiveness...) :
HER2 mediates
epidermal growth factor induced down-regulation of
E-cadherin in human ovarian cancer cells ... However, whether HER2 mediates
EGF induced down-regulation of
E-cadherin remains unknown ... In this study, we examined the potential role of HER2 in
EGF induced down-regulation of
E-cadherin and increased cell invasion ... This study demonstrates an important role for HER2 in mediating the
effects of
EGF on Snail, Slug and
E-cadherin expression as well as invasiveness in human ovarian cancer cells
Bourboulia et al., Oncotarget 2013
:
Moreover, exogenous treatment with recombinant Ala+TIMP-2 blocked
EGF induced down-regulation of
E-cadherin
Fujii et al., Exp Cell Res 1996
(Carcinoma, Squamous Cell...) :
Since the colony dissociation apparently involved loss of cell-cell adhesion, we also studied the
effects of
EGF on
E-cadherin expression and its function