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IFI27 — RHOA

Text-mined interactions from Literome

Seasholtz et al., Circ Res 2001 (Hypertension) : Wortmannin ( 10 nmol/L ) fully inhibited the decrease in p27 ( Kip1 ) induced by RhoA , and a membrane targeted catalytic subunit of phosphatidylinositol-3 kinase ( PI3K [ p110 ( CAAX ) ] ) decreased p27 ( Kip1 ) expression, suggesting that RhoA signals through PI3K
Wu et al., Cancer Res 2006 (Breast Neoplasms...) : Expression of p27deltaNLS in MCF7 breast cancer cells down-regulated RhoA and increased motility, survival, and Akt levels without an effect on cell cycle distribution
Larrea et al., Proc Natl Acad Sci U S A 2009 (MAP Kinase Signaling System) : We present evidence that RSK1 drives p27 phosphorylation at T198 to increase RhoA-p27 binding and cell motility ... Thus T198 phosphorylation not only stabilizes p27 and mislocalizes p27 to the cytoplasm but also promotes RhoA-p27 interaction and RhoA pathway inhibition
Larrea et al., Cell cycle (Georgetown, Tex.) 2009 (Neoplasms) : Further characterization of post-translational modifications governing p27 localization and its action on RhoA and the actin cytoskeleton may provide critical insights into human cancer metastasis
Lee et al., Frontiers in bioscience (Landmark edition) 2011 (Neoplasm Invasiveness...) : TM4SF5 induces epithelial-mesenchymal transition (EMT) by morphological changes resulting from inactivation of RhoA mediated by stabilized cytosolic p27kip1
Konecny et al., Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences 2010 : After transport in cytoplasm, p27 Kip1 binds to RhoA thus prevent activation of RhoA by GEFs, thus inhibit GDP-GTP exchange mediated by GEFs
Wei et al., Cell Signal 2013 (Stomach Neoplasms) : The depletion of p27 increased RhoA ( Ras homolog family member A ) activity, upregulated RECK, and downregulated E-cadherin and Sp1 in STAT3 depleted cells
Ruiz-Ontañon et al., Stem Cells 2013 : Of note, p27 is upregulated in TM cells and inhibits RhoA activity
Weber et al., J Biol Chem 1997 : C3 transferase also inhibited PDGF induced p27 ( KIP1 ) degradation, thus further implicating RhoA in p27 ( KIP1 ) regulation
Hu et al., J Biol Chem 1999 : RhoA stimulates p27 ( Kip ) degradation through its regulation of cyclin E/CDK2 activity ... In the absence of serum, expression of constitutively active RhoA ( 63 ) resulted in significant stimulation of cyclin E/CDK2 activity and degradation of p27 ( Kip ) ... In addition, expression of dominant negative RhoA blocked serum induced cyclin E/CDK2 activity and p27 ( Kip ) degradation ... Taken together, these data show that RhoA regulates p27 ( Kip ) degradation through its regulation of cyclin E/CDK2 activity