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CTNNB1 — FZD7
Text-mined interactions from Literome
Merle et al., Gastroenterology 2004
(Carcinoma, Hepatocellular...) :
These observations suggest that the Wnt/beta-catenin signal transduction pathway is involved much more commonly in the molecular pathogenesis of HCC than previously recognized because
FZD7 overexpression occurred early in the disease process,
stabilized wild-type
beta-catenin levels, and contributed to enhanced tumor cell migration
Vincan et al., Dev Dyn 2010
(Colorectal Neoplasms) :
We demonstrate that the
FZD7 promoter is
regulated by
beta-catenin in colorectal cancer cells and observed decreased promoter activity in cells grown on fibronectin but not collagen I or collagen IV
Tanaka et al., Proc Natl Acad Sci U S A 1998
(Esophageal Neoplasms) :
Finally, coexpression of
FzE3 with Lef-1 transcription factor
enhanced beta-catenin translocation to the nucleus ... These observations suggest that
FzE3 gene expression may down-regulate APC function and
enhance beta-catenin mediated signals in poorly differentiated human esophageal carcinomas