Chong et al., J Cereb Blood Flow Metab 2003
:
Consistent with the modulation of Apaf-1 and the release of cytochrome c, EPO also inhibits the activation of caspase-9 and caspase-3-like activities
Wu et al., Apoptosis 2007
:
EPO induced sustained phosphorylation of Akt and its substrate, GSK-3beta, reduced caspase-3 activities in PC12 cells
Xie et al., Eye (Lond) 2012
(Disease Models, Animal...) :
Intravitreal injection of EPO 400 ng is safe, and EPO may suppress caspase-3 activation and enhance Bcl-X ( L ) expression, resulting in inhibition of apoptosis and protection of photoreceptor cells