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ARF6 — RAC3
Text-mined interactions from Literome
Conger et al., Ren Fail 1992
(Acute Kidney Injury...) :
Functionally similar ischemic
acute renal failure ( ARF ) , as estimated by glomerular filtration rates ( GFR ), was
induced by
renal artery clamping ( RAC ) or intrarenal norepinephrine ( NE ) in rats and renovascular reactivity was examined at 1 week
Santy et al., Curr Biol 2005
:
ARF6 is intimately involved in the regulation of Rac activity ; however, the mechanisms by which
ARF activation
leads to activation of
Rac remain poorly understood ...
ARF6 is intimately
involved in the regulation of
Rac activity ; however, the mechanisms by which ARF activation leads to activation of Rac remain poorly understood
Koo et al., BMC cell biology 2007
:
Although Kalirin is recruited onto membranes by Arf6-GDP, subsequent
Rac activation and membrane ruffling
requires Arf6 activation ... From these results, we suggest that
Arf6 can
regulate through its GTPase cycle the activation of
Rac
Hall et al., Anal Biochem 2008
:
The
involvement of the small GTPase
Arf6 in
Rac activation, cell migration, and cancer invasiveness suggests that it is activated in a spatially and temporally regulated manner
Hajdo-Milasinovic et al., J Cell Sci 2009
:
Moreover, in Rac3 expressing cells,
Arf6 activity is strongly reduced and the Arf6-GAP activity of GIT1 is
required for
Rac3 downstream signaling