Gene interactions and pathways from curated databases and text-mining

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ARF6 — RAC3

Text-mined interactions from Literome

Conger et al., Ren Fail 1992 (Acute Kidney Injury...) : Functionally similar ischemic acute renal failure ( ARF ) , as estimated by glomerular filtration rates ( GFR ), was induced by renal artery clamping ( RAC ) or intrarenal norepinephrine ( NE ) in rats and renovascular reactivity was examined at 1 week
Santy et al., Curr Biol 2005 : ARF6 is intimately involved in the regulation of Rac activity ; however, the mechanisms by which ARF activation leads to activation of Rac remain poorly understood ... ARF6 is intimately involved in the regulation of Rac activity ; however, the mechanisms by which ARF activation leads to activation of Rac remain poorly understood
Koo et al., BMC cell biology 2007 : Although Kalirin is recruited onto membranes by Arf6-GDP, subsequent Rac activation and membrane ruffling requires Arf6 activation ... From these results, we suggest that Arf6 can regulate through its GTPase cycle the activation of Rac
Hall et al., Anal Biochem 2008 : The involvement of the small GTPase Arf6 in Rac activation, cell migration, and cancer invasiveness suggests that it is activated in a spatially and temporally regulated manner
Hajdo-Milasinovic et al., J Cell Sci 2009 : Moreover, in Rac3 expressing cells, Arf6 activity is strongly reduced and the Arf6-GAP activity of GIT1 is required for Rac3 downstream signaling