◀ Back to PTH
CA3 — PTH
Text-mined interactions from Literome
Garg et al., Pflugers Arch 1976
:
Failure of
parathyroid hormone and cyclic AMP to
inhibit renal
carbonic anhydrase
Dawborn et al., Br J Pharmacol 1977
:
The hypothesis that acetazolamide and
parathyroid hormone (PTH) ,
inhibit renal
carbonic anhydrase by a cyclic adenosine 3',5'-monophosphate ( cyclic AMP ) -dependent mechanism was also tested.2In vitro, acetazolamide, frusemide and ethacrynic acid at high concentrations ( 10 ( -3 ) M ) all produced some inhibition of basal and stimulated rat kidney plasma membrane adenylate cyclase
Hunter et al., J Bone Miner Res 1988
:
The transient increase in acidity may be due to
activation of
carbonic anhydrase by
PTH
Arlot-Bonnemains et al., Proc Natl Acad Sci U S A 1985
:
The
effect of calcitonin ( CT ) and
parathyroid hormone (PTH) on
carbonic anhydrase ( carbonate hydrolyase, EC 4.2.1.1. ) activity was tested in human erythrocyte hemolysates and with purified carbonic anhydrases I and II
Anderson et al., Calcif Tissue Int 1985
:
Stimulation of
carbonic anhydrase in osteoclasts by
parathyroid hormone ... Because increased fluorescence of acridine orange is a sign of greater acidity, these results suggest that ( 1 )
PTH stimulates the acidity of osteoclasts, ( 2 ) carbonic anhydrase activity is necessary for maximum acidity, and ( 3 )
carbonic anhydrase is
activated by PTH
DuBose et al., Artif Organs 1982
(Acid-Base Imbalance...) :
PTH mediates bone buffering capacity by activating intracellular shifts of calcium, phosphorus, and carbonate or by stimulation of bone
carbonic anhydrase
Nascimento et al., J Pharmacol Exp Ther 1977
:
It has been recently demonstrated that
parathyroid hormone (PTH) inhibits renal cortical
carbonic anhydrase ... These data do not support the hypothesis that
PTH inhibits bicarbonate and phosphate reabsorption by
inhibiting carbonic anhydrase