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HDAC2 — RB1

Pathways - manually collected, often from reviews:

• KEGG Cell cycle: HDAC1/HDAC2 → RB1 (protein-protein, binding/association)
• WikiPathways Cell Cycle: HDAC1/HDAC2/HDAC3/HDAC5/HDAC6/HDAC7/HDAC8/HDAC4 → RB1 (unknown)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: HDAC2 — RB1 (physical association, affinity chromatography technology) Sun et al., J Biol Chem 2007
• IRef Biogrid Interaction: HDAC2 — RB1 (physical association, affinity chromatography technology) Khan et al., J Biol Chem 2001*
• IRef Biogrid Interaction: HDAC2 — RB1 (direct interaction, pull down) Chan et al., Oncogene 2001*
• IRef Biogrid Interaction: HDAC2 — RB1 (physical association, affinity chromatography technology) Lai et al., Mol Cell Biol 1999
• IRef Dip Interaction: Complex of 18 proteins (anti tag coimmunoprecipitation) Hu et al., Proc Natl Acad Sci U S A 2009
• IRef Dip Interaction: HDAC2 — RB1 (physical association, experimental interaction detection) Brehm et al., Nature 1998
• IRef Hprd Interaction: Complex of 26 proteins (in vivo) Lai et al., Mol Cell Biol 1999
• IRef Intact Interaction: Complex of 92 proteins (association, anti tag coimmunoprecipitation) Joshi et al., Molecular systems biology 2013
• IRef Intact Interaction: HDAC2 — RB1 (physical association, pull down) Brehm et al., EMBO J 1999*

Text-mined interactions from Literome

Finzer et al., Oncogene 2001 (Cell Transformation, Neoplastic...) : HDAC inhibition also triggered an E7-dependent degradation of pRb , while the levels of E2F remained unaffected
Takaki et al., Biochem Biophys Res Commun 2004 : Cdk mediated phosphorylation of pRB regulates HDAC binding in vitro ... Phosphorylation of pRB by Cdk4-cyclin D2, Cdk2-cyclin E, and Cdk2-cyclin A inhibited association of pRB with HDAC