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HDAC2 — TXN

Text-mined interactions from Literome

Marks et al., Cell cycle (Georgetown, Tex.) 2005 (Neoplasms) : We also found that thioredoxin (TRX) might play a significant role in HDAC inhibitor induced cell death, and HDAC inhibitors increase TRX levels in normal cells but not transformed cells, which is likely to be one of the reasons why HDAC inhibitors preferentially kill cancer cells
Zhou et al., Blood 2011 (Leukemia, Myeloid, Acute) : We show that disruption of PRC2 , either by DZNep treatment or EZH2 knockdown, reactivates TXNIP, inhibits thioredoxin activity, and increases reactive oxygen species ( ROS ), leading to apoptosis