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CLDN2 — TNF

Text-mined interactions from Literome

Mankertz et al., Cell Tissue Res 2009 : Our aim has been to characterize the molecular mechanisms regulating the expression of the channel forming tight-junctional protein claudin-2 in response to the pro-inflammatory cytokine tumor necrosis factor-alpha (TNFalpha) , which is elevated, for example, in active Crohn 's disease ... The claudin-2 protein level was increased by TNFalpha without changes in subcellular tight-junctional protein localization as revealed by confocal laser scanning microscopy ... Thus, the up-regulation of claudin-2 by TNFalpha is attributable to the regulation of the expression of the gene, as a result of which epithelial barrier function is disturbed, for example, during chronic intestinal inflammation
Fischer et al., Am J Physiol Gastrointest Liver Physiol 2013 : In addition, TNF-a induced a downregulation of claudin-1, claudin-2 , claudin-4, and occludin as well as activation of phosphatidylinositol 3-kinase signaling in T-84 but not Caco-2 cells, which was reversed by adalimumab