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GAB1 — MET

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of CRK-GAB1 → MET (increases, CRK/GAB1 Activity)
  Evidence: Page 54 - "Crk appears to bind Gab1 in response to Met but not other receptor tyrosine kinases."
• OpenBEL Selventa BEL large corpus: GAB1 → MET (directlyIncreases, MET Activity, GAB1 Activity) Sakkab et al., J Biol Chem 2000
  Evidence: Upon activation, the HGF-receptor c-Met binds and phosphorylates the multisite docking protein Gab1. Besides binding motifs for phosphatidylinositol 3-kinase and Grb2, Gab 1 contains multiple Tyr-X-X-Pro (YXXP) motifs which, when phosphorylated, are potential binding sites for the adapter proteins c-Crk and Crk-like (CRKL).
• OpenBEL Selventa BEL large corpus: GAB1 → MET (directlyIncreases, GAB1 Activity)
  Evidence: 10978177;9890893;10734310
• OpenBEL Selventa BEL large corpus: GAB1 → MET (directlyIncreases, GAB1 Activity)
  Evidence: 10978177;9890893;10753869;10734310
• OpenBEL Selventa BEL large corpus: GAB1 → MET (directlyIncreases, GAB1 Activity)
  Evidence: 9890893;10753869;10734310
• KEGG Bacterial invasion of epithelial cells: MET → GAB1 (protein-protein, phosphorylation)
• KEGG Renal cell carcinoma: MET → GAB1 (protein-protein, activation)
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): CRK (CRK) → HGF(dimer)/MET(dimer)/GAB1 complex (MET-GAB1-HGF) (modification, collaborate)
  Lamorte et al., Oncogene 2000, Lamorte et al., J Biol Chem 2002*, Chan et al., Oncogene 2010
  Evidence: physical interaction
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): CRK (CRK) → HGF(dimer)/MET(dimer)/GAB1/CRK complex (MET-GAB1-CRK-HGF) (modification, collaborate)
  Lamorte et al., Oncogene 2000, Lamorte et al., J Biol Chem 2002*, Chan et al., Oncogene 2010
  Evidence: physical interaction
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): HGF(dimer)/MET(dimer)/GAB1 complex (MET-GAB1-HGF) → HGF(dimer)/MET(dimer)/GAB1/CRK complex (MET-GAB1-CRK-HGF) (modification, collaborate)
  Lamorte et al., Oncogene 2000, Lamorte et al., J Biol Chem 2002*, Chan et al., Oncogene 2010
  Evidence: physical interaction
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): HGF(dimer)/MET(dimer)/GRB2/GAB1 complex (MET-GRB2-GAB1-HGF) → SHP2 (PTPN11) (modification, collaborate) Schaeper et al., J Cell Biol 2000, Maroun et al., Mol Cell Biol 2000
  Evidence: mutant phenotype
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): HGF(dimer)/MET(dimer)/GRB2/GAB1 complex (MET-GRB2-GAB1-HGF) → HGF(dimer)/MET(dimer)/GRB2/GAB1/SHP2 complex (MET-GRB2-GAB1-PTPN11-HGF) (modification, collaborate)
  Schaeper et al., J Cell Biol 2000, Maroun et al., Mol Cell Biol 2000
  Evidence: mutant phenotype
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): SHP2 (PTPN11) → HGF(dimer)/MET(dimer)/GRB2/GAB1/SHP2 complex (MET-GRB2-GAB1-PTPN11-HGF) (modification, collaborate)
  Schaeper et al., J Cell Biol 2000, Maroun et al., Mol Cell Biol 2000
  Evidence: mutant phenotype
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): HGF(dimer)/MET(dimer)/GRB2/GAB1 complex (MET-GRB2-GAB1-HGF) → HGF(dimer)/MET(dimer) complex (MET-HGF) (modification, collaborate)
  Schaeper et al., J Cell Biol 2000, Schaeper et al., Proc Natl Acad Sci U S A 2007, Nguyen et al., J Biol Chem 1997*
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): HGF(dimer)/MET(dimer)/GRB2/GAB1 complex (MET-GRB2-GAB1-HGF) → GRB2/GAB1 complex (GRB2-GAB1) (modification, collaborate)
  Schaeper et al., J Cell Biol 2000, Schaeper et al., Proc Natl Acad Sci U S A 2007, Nguyen et al., J Biol Chem 1997*
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): HGF(dimer)/MET(dimer) complex (MET-HGF) → GRB2/GAB1 complex (GRB2-GAB1) (modification, collaborate)
  Schaeper et al., J Cell Biol 2000, Schaeper et al., Proc Natl Acad Sci U S A 2007, Nguyen et al., J Biol Chem 1997*
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): Gab1 (GAB1) → HGF(dimer)/MET(dimer) complex (MET-HGF) (translocation, activates)
  Gomes et al., J Biol Chem 2008*
  Evidence: assay
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): Erk1-2 (MAPK3/MAPK1) → HGF(dimer)/MET(dimer)/GRB2/GAB1/SHP2 complex (MET-GRB2-GAB1-PTPN11-HGF) (modification, collaborate)
  Schaeper et al., J Cell Biol 2000, Maroun et al., Mol Cell Biol 2000
  Evidence: mutant phenotype
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): GAB1/N-WASP complex (GAB1-WASL) → HGF(dimer)/MET(dimer) complex (MET-HGF) (modification, collaborate)
  Abella et al., J Cell Sci 2010
  Evidence: physical interaction
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): GAB1/N-WASP complex (GAB1-WASL) → HGF(dimer)/MET(dimer)/GAB1/N-WASP complex (MET-GAB1-WASL-HGF) (modification, collaborate)
  Abella et al., J Cell Sci 2010
  Evidence: physical interaction
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): HGF(dimer)/MET(dimer) complex (MET-HGF) → HGF(dimer)/MET(dimer)/GAB1/N-WASP complex (MET-GAB1-WASL-HGF) (modification, collaborate)
  Abella et al., J Cell Sci 2010
  Evidence: physical interaction
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): CRKL (CRKL) → HGF(dimer)/MET(dimer)/GAB1 complex (MET-GAB1-HGF) (modification, collaborate)
  Sakkab et al., J Biol Chem 2000, Posern et al., Oncogene 1998*
  Evidence: physical interaction
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): CRKL (CRKL) → HGF(dimer)/MET(dimer)/GAB1/CRKL complex (MET-GAB1-CRKL-HGF) (modification, collaborate)
  Sakkab et al., J Biol Chem 2000, Posern et al., Oncogene 1998*
  Evidence: physical interaction
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): HGF(dimer)/MET(dimer)/GAB1 complex (MET-GAB1-HGF) → HGF(dimer)/MET(dimer)/GAB1/CRKL complex (MET-GAB1-CRKL-HGF) (modification, collaborate)
  Sakkab et al., J Biol Chem 2000, Posern et al., Oncogene 1998*
  Evidence: physical interaction
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): HGF(dimer)/MET(dimer)/GAB1 complex (MET-GAB1-HGF) → PI3K complex (PIK3CA-PIK3R1) (modification, activates)
  Yu et al., J Biol Chem 2001, Yu et al., J Biol Chem 2002*, Graziani et al., J Biol Chem 1991*, Schaeper et al., Proc Natl Acad Sci U S A 2007, Ponzetto et al., Cell 1994
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): Erk1-2 (MAPK3/MAPK1) → HGF(dimer)/MET(dimer)/GAB1/SHP2 complex (MET-GAB1-PTPN11-HGF) (modification, collaborate)
  Schaeper et al., J Cell Biol 2000, Maroun et al., Mol Cell Biol 2000
  Evidence: mutant phenotype
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): PAK4 (PAK4) → HGF(dimer)/MET(dimer)/GAB1 complex (MET-GAB1-HGF) (modification, collaborate)
  Wells et al., J Cell Sci 2002*, Paliouras et al., Mol Cell Biol 2009*
  Evidence: physical interaction
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): PAK4 (PAK4) → HGF(dimer)/MET(dimer)/GAB1/PAK4 complex (MET-GAB1-PAK4-HGF) (modification, collaborate)
  Wells et al., J Cell Sci 2002*, Paliouras et al., Mol Cell Biol 2009*
  Evidence: physical interaction
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): HGF(dimer)/MET(dimer)/GAB1 complex (MET-GAB1-HGF) → HGF(dimer)/MET(dimer)/GAB1/PAK4 complex (MET-GAB1-PAK4-HGF) (modification, collaborate)
  Wells et al., J Cell Sci 2002*, Paliouras et al., Mol Cell Biol 2009*
  Evidence: physical interaction
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): Src (SRC) → HGF(dimer)/MET(dimer)/GAB1 complex (MET-GAB1-HGF) (modification, activates)
  Chan et al., J Biol Chem 2003*, Chan et al., Oncogene 2010
  Evidence: mutant phenotype, assay
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): Src (SRC) → HGF(dimer)/MET(dimer)/GAB1/SHP2 complex (MET-GAB1-PTPN11-HGF) (modification, activates)
  Chan et al., J Biol Chem 2003*, Chan et al., Oncogene 2010
  Evidence: mutant phenotype, assay
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): HGF(dimer)/MET(dimer)/GAB1/N-WASP/NCK1-2 complex (MET-GAB1-WASL-NCK2_NCK1-HGF) → HGF(dimer)/MET(dimer)/GAB1/N-WASP complex (MET-GAB1-WASL-HGF) (modification, collaborate)
  Abella et al., J Cell Sci 2010
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): HGF(dimer)/MET(dimer)/GAB1/N-WASP/NCK1-2 complex (MET-GAB1-WASL-NCK2_NCK1-HGF) → NCK1-2 (NCK2/NCK1) (modification, collaborate) Abella et al., J Cell Sci 2010
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): HGF(dimer)/MET(dimer)/GAB1/N-WASP complex (MET-GAB1-WASL-HGF) → NCK1-2 (NCK2/NCK1) (modification, collaborate) Abella et al., J Cell Sci 2010
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): Gab1 (GAB1) → HGF(dimer)/MET(dimer) complex (MET-HGF) (modification, collaborate)
  Schaeper et al., J Cell Biol 2000, Sachs et al., J Cell Biol 2000*, Lock et al., Mol Biol Cell 2002*, Schaeper et al., Proc Natl Acad Sci U S A 2007, Chan et al., Oncogene 2010, Weidner et al., Nature 1996*
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): SHP2 (PTPN11) → HGF(dimer)/MET(dimer)/GAB1 complex (MET-GAB1-HGF) (modification, collaborate)
  Chan et al., Oncogene 2010
  Evidence: mutant phenotype
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): SHP2 (PTPN11) → HGF(dimer)/MET(dimer)/GAB1/SHP2 complex (MET-GAB1-PTPN11-HGF) (modification, collaborate)
  Chan et al., Oncogene 2010
  Evidence: mutant phenotype
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): HGF(dimer)/MET(dimer)/GAB1 complex (MET-GAB1-HGF) → HGF(dimer)/MET(dimer)/GAB1/SHP2 complex (MET-GAB1-PTPN11-HGF) (modification, collaborate)
  Chan et al., Oncogene 2010
  Evidence: mutant phenotype
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): Gab1 (GAB1) → HGF(dimer)/MET(dimer)/GAB1 complex (MET-GAB1-HGF) (modification, collaborate)
  Schaeper et al., J Cell Biol 2000, Sachs et al., J Cell Biol 2000*, Lock et al., Mol Biol Cell 2002*, Schaeper et al., Proc Natl Acad Sci U S A 2007, Chan et al., Oncogene 2010, Weidner et al., Nature 1996*
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): HGF(dimer)/MET(dimer) complex (MET-HGF) → HGF(dimer)/MET(dimer)/GAB1 complex (MET-GAB1-HGF) (modification, collaborate)
  Schaeper et al., J Cell Biol 2000, Sachs et al., J Cell Biol 2000*, Lock et al., Mol Biol Cell 2002*, Schaeper et al., Proc Natl Acad Sci U S A 2007, Chan et al., Oncogene 2010, Weidner et al., Nature 1996*
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): Erk1-2-active (MAPK3/MAPK1) → HGF(dimer)/MET(dimer)/GAB1 complex (MET-GAB1-HGF) (modification, activates)
  Yu et al., J Biol Chem 2001
  Evidence: mutant phenotype

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind_translation Interaction: MET — GAB1 (coimmunoprecipitation) Petrelli et al., Nature 2002
• IRef Biogrid Interaction: GAB1 — MET (physical association, affinity chromatography technology) Fixman et al., J Biol Chem 1997*
• IRef Biogrid Interaction: GAB1 — MET (physical association, affinity chromatography technology) Schaeper et al., J Cell Biol 2000
• IRef Hprd Interaction: GAB1 — MET (in vitro) Gual et al., Oncogene 2000, Sachs et al., J Cell Biol 2000*
• IRef Hprd Interaction: GAB1 — MET (in vivo) Gual et al., Oncogene 2000, Sachs et al., J Cell Biol 2000*
• IRef Hprd Interaction: Complex of GRB2-GAB1-MET-MET-GAB1-GRB2-GAB1-MET-GRB2 (in vivo) Schaeper et al., J Cell Biol 2000
• IRef Intact Interaction: GAB1 — MET (physical association, anti tag coimmunoprecipitation) Lock et al., J Biol Chem 2000*
• IRef Ophid Interaction: GAB1 — MET (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• STRING interaction: GAB1 — MET (interaction, mapped from kegg_pathways)
• STRING interaction: GAB1 — MET (interaction, mapped from kegg_pathways)
• STRING interaction: MET — GAB1 (interaction, mapped from kegg_pathways)
• STRING interaction: MET — GAB1 (interaction, mapped from kegg_pathways)

Text-mined interactions from Literome

Lamorte et al., Oncogene 2000 (Cell Transformation, Neoplastic) : We propose that the loss of adhesion dependent signals required for cell cycle progression is compensated through Met induced Gab1/Crk signals
Weidner et al., Nature 1996 : Expression of Gab1 in epithelial cells is sufficient to induce the c-Met-specific activities, including branching morphogenesis
Nguyen et al., J Biol Chem 1997 : Met receptor mutants that fail to induce branching tubulogenesis are impaired in their ability to interact with Gab1 , suggesting that Gab1 may play a role in these processes