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EGF — KRAS

Pathways - manually collected, often from reviews:

• NCI Pathway Database Internalization of ErbB1: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → EGFR/EGFR/EGF/EGF/GRB2/SOS1 complex (EGFR-EGF-GRB2-SOS1) (modification, collaborate)
  Haugh et al., J Biol Chem 1999, Pennock et al., Mol Cell Biol 2003, Wiley et al., J Biol Chem 1991, Di Guglielmo et al., EMBO J 1994, Herbst et al., J Biol Chem 1994
  Evidence: assay
• NCI Pathway Database Internalization of ErbB1: EGFR/EGFR/EGF/EGF/GRB2/SOS1 complex (EGFR-EGF-GRB2-SOS1) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
  Haugh et al., J Biol Chem 1999, Pennock et al., Mol Cell Biol 2003, Wiley et al., J Biol Chem 1991, Di Guglielmo et al., EMBO J 1994, Herbst et al., J Biol Chem 1994
  Evidence: assay
• NCI Pathway Database Internalization of ErbB1: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → EGFR/EGFR/EGF/EGF/p46 SHC/GRB2/SOS1 complex (EGFR-EGF-SHC1-GRB2-SOS1) (modification, collaborate)
  Haugh et al., J Biol Chem 1999
  Evidence: assay
• NCI Pathway Database Internalization of ErbB1: EGFR/EGFR/EGF/EGF/p46 SHC/GRB2/SOS1 complex (EGFR-EGF-SHC1-GRB2-SOS1) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
  Haugh et al., J Biol Chem 1999
  Evidence: assay
• NCI Pathway Database Internalization of ErbB1: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → EGFR/EGFR/EGF/EGF/p52 SHC/GRB2/SOS1 complex (EGFR-EGF-SHC1-GRB2-SOS1) (modification, collaborate)
  Haugh et al., J Biol Chem 1999
  Evidence: assay
• Reactome Reaction: EGF → KRAS (reaction) Paez et al., Science 2004, Sordella et al., Science 2004, Shimamura et al., Cancer Res 2005, Janes et al., Oncogene 1994, Chardin et al., Science 1993, Xie et al., J Biol Chem 1995

Text-mined interactions from Literome

Giehl et al., Oncogene 2000 (Pancreatic Neoplasms) : Stimulation of cells with epidermal growth factor (EGF) or fetal calf serum ( FCS ) resulted in activation of N-Ras, but not K-Ras , as well as activation of c-Raf, MEK-1, and p42 MAPK
Kranenburg et al., Curr Biol 2001 (MAP Kinase Signaling System) : Extraction of cholesterol with methyl-beta-cyclodextrin disrupts complex formation between caveolin and K- and N-Ras and, strikingly, enables EGF to activate both K-Ras and N-Ras
Elad-Sfadia et al., J Biol Chem 2004 : Galectin-3 antisense RNA inhibited the epidermal growth factor stimulated increase in K-Ras-GTP but enhanced ERK activation and augmented K-Ras ( G12V ) transformation activity
Bergot et al., Rev Mal Respir 2007 (Adenocarcinoma...) : EGF binding to EGFR leads to K-Ras activation, promoting signaling of division, survival, and cell invasion
Lu et al., J Cell Biol 2009 : In this study, we report that epidermal growth factor triggers Kirsten Ras (KRas) translocation onto endosomal membranes ( independently of calmodulin and protein kinase C phosphorylation ) through a clathrin dependent pathway