Katayama et al., Mol Cancer Ther 2007
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Conversely, epidermal growth factor and basic fibroblast growth factor enhanced P-gp expression, but the MDR1 mRNA levels were unchanged in epidermal growth factor stimulated cells
Meyers et al., Biochem Pharmacol 1993
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An interrelationship of the two membrane proteins in actinomycin D-resistant Chinese hamster lung cells ( DC-3F/AD X ) in terms of the effect of EGF on Pgp phosphorylation was investigated
Yang et al., Biochem Pharmacol 1997
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Since recent studies suggest that activation of phospholipase C (PLC) could increase the phosphorylation of P-gp, and activation of the EGFR would also activate PLC, we investigated whether the effect of epidermal growth factor (EGF) on the phosphorylation of P-gp was mediated through PLC