Gene interactions and pathways from curated databases and text-mining

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CTTN — PAK1

Pathways - manually collected, often from reviews:

  • BioCarta agrin in postsynaptic differentiation: agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN) → Ach R/RAPSYN complex (CHRM1_CHRNA1-RAPSN) (modification, collaborate)
  • BioCarta agrin in postsynaptic differentiation: agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN) → utrophin (UTRN) (modification, collaborate)
  • BioCarta agrin in postsynaptic differentiation: agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN) → agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin/Ach R/RAPSYN/utrophin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN-CHRM1_CHRNA1-RAPSN-UTRN) (modification, collaborate)
  • BioCarta agrin in postsynaptic differentiation: Ach R/RAPSYN complex (CHRM1_CHRNA1-RAPSN) → agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin/Ach R/RAPSYN/utrophin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN-CHRM1_CHRNA1-RAPSN-UTRN) (modification, collaborate)
  • BioCarta agrin in postsynaptic differentiation: utrophin (UTRN) → agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin/Ach R/RAPSYN/utrophin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN-CHRM1_CHRNA1-RAPSN-UTRN) (modification, collaborate)
  • BioCarta agrin in postsynaptic differentiation: agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN) → cortactin (CTTN) (modification, collaborate)
  • BioCarta agrin in postsynaptic differentiation: agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN) → agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3) (modification, collaborate)
  • BioCarta agrin in postsynaptic differentiation: cortactin (CTTN) → agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3) (modification, collaborate)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Webb et al., Arch Biochem Biophys 2006 : However, binding of cortactin to F-actin is significantly reduced by PAK-phosphorylation
Ayala et al., J Cell Sci 2008 (Melanoma...) : In addition, through a combination of RNA interference and a wide array of cortactin phosphorylation mutants, we were able to show that three convergent regulatory inputs based on the regulation of cortactin phosphorylation by Src-family kinases, Erk1/Erk2 and PAK are necessary for invadopodia formation and extracellular matrix degradation
Grassart et al., Traffic 2010 : Pak1 phosphorylation enhances cortactin-N-WASP interaction in clathrin-caveolin independent endocytosis
Weed et al., J Cell Sci 1998 : Expression of mutant forms of the serine/threonine kinase PAK1 , a downstream effector of Rac1 and Cdc42 recently demonstrated to trigger cortical actin polymerization and membrane ruffling, also led to the translocation of cortactin to the cell cortex, although this was effectively blocked by coexpression of Rac1N17