Ikeda et al., Mol Cell Biol 2009
(Cardiomegaly...) :
miR-1 also negatively regulated the expression of Mef2a and Gata4 , key transcription factors that mediate calcium dependent changes in gene expression
Callis et al., J Clin Invest 2009
(Cardiomegaly) :
Furthermore, analysis of mice lacking miR-208a indicated that miR-208a was required for proper cardiac conduction and expression of the cardiac transcription factors homeodomain-only protein and GATA4 and the gap junction protein connexin 40
Han et al., Cardiovasc Res 2012
(Cardiomegaly...) :
GATA4 expression is primarily regulated via a miR-26b dependent post-transcriptional mechanism during cardiac hypertrophy ... Down-regulation of miR-26b in the heart is required for the up-regulation of GATA4 and the induction of pressure induced cardiac hypertrophy
Yao et al., RNA Biol 2013
:
Overexpression of miR-200b leads to the downregulation of GATA-4 mRNA and a decrease in GATA-4 protein levels