Gene interactions and pathways from curated databases and text-mining

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AGO1 — MYLIP

Text-mined interactions from Literome

Bowman et al., Bioessays 2004 : Three recent papers provide insight into how miRNAs, likely acting through a complex containing an Argonaute protein, regulate Class III HD-Zip gene expression in Arabidopsis and maize.1-3 While the precise biological activity of Argonaute proteins remains an enigma, ARGONAUTE1 in Arabidopsis is required for the proper regulation of miRNA165/166 , which targets cleavage of Class III HD-Zip mRNAs
Gazzani et al., BMC evolutionary biology 2009 : This complex auto-regulatory loop, composed of miR168 guided AGO1 catalyzed cleavage of AGO1 mRNA and AGO1 mediated stabilization of miR168 , was shown to ensure the maintenance of AGO1 homeostasis that is pivotal for the correct functioning of the miRNA pathway
Mallory et al., EMBO Rep 2009 : We have previously reported that AGO1 homeostasis is maintained through the repressive action of miR168 on AGO1 mRNA and the stabilizing effect of AGO1 protein on miR168 , but siRNA mediated AGO1 regulation has not been reported
Vaucheret et al., PloS one 2009 : Only the 21-nt miR168 is preferentially stabilized by AGO1 , and consequently, the accumulation of the 22-nt but not the 21-nt miR168 is reduced when DCL1 activity is impaired
Zhang et al., PloS one 2012 : Transfection assay revealed that both Ago1 and Ago2 synergistically induced miR-21 and miR-21* when the mir-21 plasmid was co-transfected with either