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IRF6 — SLC9A1

Text-mined interactions from Literome

Cetin et al., Surgery 2004 (Acidosis...) : LPS caused a dose dependent reduction in basolateral NHE1 activity in IEC-6 cells, but had no effect on apical NHE3 activity ... LPS selectively impairs basolateral NHE1 but not apical NHE3, leading to cytoplasmic acidification during extracellular acidosis
Cui et al., Acta Pharmacol Sin 2013 (Atherosclerosis) : Amiloride ( 1-10 µmol/L ) significantly suppressed LPS induced increases in NHE1 activity, [ Ca ( 2+ ) ] ( i ) ... LPS stimulates NHE1 activity, increases [ Ca ( 2+ ) ] ( i ), and activates calpain, which leads to endothelial cell apoptosis related to decreased Bcl-2 expression