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LEP — MMP2

Text-mined interactions from Literome

Park et al., Exp Mol Med 2001 (Arteriosclerosis...) : Leptin also induced increases of MMP-2, MMP-9 , TIMP-1, and Up-regulated the human coronary artery smooth muscle cells ( HCASMCs )
Kume et al., J Histochem Cytochem 2002 : Leptin enhanced the proliferation, migration, tube formation, and matrix metalloproteinase-2 (MMP-2) activity of human endothelial cells ( HUVECs ) in vitro
Quinton et al., Am J Reprod Immunol 2003 : Expression of leptin receptor isoforms in vitro : lack of effects of leptin on endometrial cytokine and MMP production ... The effect of leptin on cell growth and on the production of cytokines [Leukaemia Inhibitory Factor (LIF), interleukin 6 and tumour necrosis factor-alpha ] and matrix metalloproteinases ( MMP ) ( MMP2 and MMP-9 ) was also investigated ... Leptin had no effect on cytokine and MMP production by these cells
Schulz et al., Biol Reprod 2004 : Our results suggest that leptin may play a role in the establishment of the placenta during early pregnancy and that this function is dependent on MMP activity
Li et al., Diabetes 2005 : In the present study, we determined the effect of leptin on human aortic smooth muscle cell ( HASMC ) proliferation and matrix metalloproteinase (MMP)-2 expression, the signaling pathways mediating these effects, and the modulatory effect of metformin on these parameters ... Metformin also inhibited the effect of leptin on HASMC proliferation and MMP-2 expression ... Overall, these results demonstrate that leptin induced HASMC proliferation and MMP-2 expression through a PKC dependent activation of NAD ( P ) H oxidase with subsequent activation of the ERK1/2/NF-kappaB pathways and that therapeutic metformin concentrations effectively inhibit these biological effects
Madani et al., Cardiovasc Res 2006 : Accordingly, upon quantitative PCR analysis we found that leptin increased expression of matrix metalloproteinase-2 (MMP-2) ... Our findings show that leptin regulates cell size, stimulates MMP-2 expression, and alters the profile, but not the total content, of collagen in human cardiomyocytes
Moon et al., Biochem Biophys Res Commun 2007 : Leptin induced matrix metalloproteinase-2 secretion is suppressed by trans-10,cis-12 conjugated linoleic acid ... The present study is designed to evaluate whether trans-10,cis-12 conjugated linoleic acid ( t-CLA ) can suppress leptin induced MMP-2 secretion in 3T3-L1 cells ... However, increasing concentration of t-CLA significantly reduced leptin induced MMP-2 secretion and triglyceride ( TG ) content
Schram et al., J Mol Cell Cardiol 2008 : Increased expression and cell surface localization of MT1-MMP plays a role in stimulation of MMP-2 activity by leptin in neonatal rat cardiac myofibroblasts ... Here we investigated the effects of leptin , circulating levels of which are typically increased in obese individuals, on MMP and collagen expression and MMP activity in isolated cardiac myofibroblasts
Yeh et al., Glia 2009 (Brain Neoplasms...) : In addition, we found that the expression of matrix metalloproteinase-13 (MMP-13) but not of MMP-2 and MMP-9 was increased in response to leptin stimulation
McMurtry et al., Clin Exp Metastasis 2009 (Breast Neoplasms...) : Here we showed that leptin increased the invasiveness and the matrix metallo-proteinase-2 (MMP-2) activity of the MCF-7 breast cancer cell line ... Leptin stimulated the phosphorylation of extracellular signals regulated kinases, signal transducers and activators of transcription 3 and Jun N-terminal kinases (JNK) ; however, only inhibition of JNK decreased leptin mediated activation of MMP-2 ... Here we report the novel findings that leptin increased invasion of breast cancer cells by activating JNK, resulting in increased MMP-2 activity
Bao et al., Mol Biol Rep 2010 : Leptin significantly increased both gene and protein levels of MMP-2, MMP-9 , cathepsin D, and collagen II, while decreased bFGF markedly in cartilage
Tao et al., Arterioscler Thromb Vasc Biol 2013 (Aortic Aneurysm, Abdominal...) : Leptin and leptin receptor antigen were evident in all AAAs, and leptin, MMP-9 , and MMP-12 mRNA was increased relative to age matched nondilated controls