Gene interactions and pathways from curated databases and text-mining

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IGF1 — SOD1

Text-mined interactions from Literome

Jiang et al., J Exp Med 2007 (Cardiomyopathy, Hypertrophic...) : HIF-1alpha coimmunoprecipitates with a Cu chaperone for superoxide dismutase-1 ( CCS ), and gene silencing of CCS, but not superoxide dismutase-1 , prevents IGF-1- or Cu-induced HIF-1alpha activation and VEGF expression
Walton-Betancourth et al., J Endocrinol Invest 2007 (Growth Disorders...) : Baseline serum IGF-I, IGFbinding protein 3 (IGFBP-3) and acid-labile subunit (ALS) were low, and in an IGF-I generation test, IGF-I did not increase into the normal range and IGFBP-3 and ALS did not change
Courtland et al., J Bone Miner Res 2010 : In serum, IGF-1 is stabilized by several IGF-1 binding proteins (IGFBPs) and the acid labile subunit (ALS)
Baxter et al., J Biol Chem 1989 : Pure ALS had no intrinsic IGF binding activity and no effect on the binding of IGF-I or IGF-II to BP-53
Scharf et al., Hepatology 1996 : It can be concluded that biosynthesis of individual IGFBPs and of ALS are compartmentalized in adult rat liver and are distinctly regulated by insulin, IGF-I , and GH
Barreca et al., Eur J Endocrinol 1997 : We have studied the effects of the somatostatin analog octreotide, IGF-II des ( 1-3 ) IGF-I , transforming growth factor (TGF)-beta 1 and tri-iodothyronine ( T3 ) on ALS secretion into the medium conditioned by rat hepatocytes in primary culture