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INS — PTHLH

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Zhang et al., Diabetes 2003 (MAP Kinase Signaling System) : Parathyroid hormone related protein induces insulin expression through activation of MAP kinase-specific phosphatase-1 that dephosphorylates c-Jun NH2-terminal kinase in pancreatic beta-cells ... We examined the mechanism of PTHrP induced insulin expression ... PTHrP induced dephosphorylation of JNK1/2, and PTHrP induced insulin expression was blocked by a dominant negative type JNK-APF ... We suspected that dual specificity MAP kinase phosphatases ( MKPs ) may be involved in the PTHrP induced insulin expression by inactivating JNK1/2 ... PTHrP induced insulin expression was blocked by the MKP-1 expression inhibitor Ro-31-8220, indicating that the PTHrP effect is mediated by MKP-1
Cramer et al., Prostate 1996 (Adenocarcinoma...) : Epidermal growth factor (EGF) was the major inducer of PTHrP expression, while cholera toxin, bovine pituitary extract, hydrocortisone, and insulin had minimal or no effect on PTHrP transcript levels
Falzon et al., Endocrinology 1996 (Osteosarcoma) : Insulin and epidermal growth factor also induced PTHrP mRNA expression in a time dependent manner analogous to serum, indicating that the effects of serum may be mediated, at least partially, through these agents
Porter et al., Endocrinology 1998 (Disease Progression...) : These studies showed that PTHrP overexpression markedly increased islet mass and insulin secretion and resulted in hypoglycemia