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CD58 — IFNG
Text-mined interactions from Literome
Visse et al., Biol Res 2003
:
While both CD28/B7-1 and
CD2/LFA-3 costimulation
resulted in the up-regulation of IL-4 and
IFN-gamma promoters, IL-2 promoter activity and production of IL-2 were only seen after B7-1 costimulation
Swerlick et al., J Invest Dermatol 1991
:
ICAM-1, but not
LFA-3 or CD44, was
increased in expression in a dose- and time dependent manner by interleukin 1 (IL-1) alpha, tumor necrosis factor (TNF) alpha, lipopolysaccharide (LPS), or
interferon (IFN) gamma
Ebert et al., Am J Physiol Gastrointest Liver Physiol 2009
(MAP Kinase Signaling System) :
Although both TNF-alpha and IFN-gamma increased IL-8 synthesis and
CD58 expression by the HT-29 cells, only
IFN-gamma reduced IL-8 production by IELs
Weber et al., Brain 1994
(Multiple Sclerosis) :
IFN-gamma alone or in combination with TNF-alpha strongly enhanced expression of HLA class I, HLA-DR, -DP, -DQ, LFA-1 alpha and ICAM-1, but did not
affect expression of LFA-2 ( CD2 ) and
LFA-3 ( CD58 )
Chong et al., Cancer Immunol Immunother 1994
:
ICAM-1 and
LFA-3 enhance the ability of anti-CD3 mAb to stimulate
interferon gamma production in interleukin-2 activated T cells
Wingren et al., J Immunol 1993
:
mAb blocking experiments suggested the
involvement of the
CD2/LFA-3 but not the LFA-1/ICAM-1 pathway in monocyte regulation of T cell synthesis of
IFN-gamma ... This suggests that the ability of
CHO-LFA-3 but not CHO-DR4/ICAM-1 cells to
induce IFN-gamma production was attributed to signal transduction rather than cell adhesion only
Iwata et al., Curr Eye Res 1997
:
Neither
IFN-gamma nor TNF-alpha
had any effect on
LFA-3 expression on the cultured HCE cells
Labuda et al., Immunology 1998
:
This response profile differs from that observed in B7 or LFA-3 costimulated T cells because our previous results showed that B7-CD28 costimulation was accompanied by high levels of IL-2, IFN-gamma and TNF, whereas
LFA-3 was a potent
inducer of
IFN-gamma and TNF, but had little influence on IL-2 production