◀ Back to IFNG
HNRNPH1 — IFNG
Text-mined interactions from Literome
Chiodoni et al., J Exp Med 1999
(Colonic Neoplasms) :
DCs isolated from C-26/GM/CD40L tumors grown in ( BALB/c x C57BL/6 ) F1 mice ( H-2d x b )
stimulated interferon gamma production by both anti-AH-1 and KSP CTLs, whereas tumor infiltrating DCs ( TIDCs ) of BALB/c mice stimulated only anti-AH-1 CTLs
Ahuja et al., J Immunol 1999
(Leishmaniasis, Visceral) :
Adoptive transfer of
DCs pulsed ex vivo with soluble L. donovani Ags ( SLDA ) to naive mice
induced the Ag-specific production of
IFN-gamma , and increased the percentage of activation markers on spleen lymphocytes
Nagayama et al., J Immunol 2000
:
The ligation of
DCs as well as Con A blasts by IL-12
induced the production of GM-CSF, IL-1beta, IL-6, TNF-alpha, and
IFN-gamma at the transcription levels
Zou et al., J Immunol 2000
:
Thus
DCs differentiating from MPhis
induce T cell
IFN-gamma through beta-chemokines with little or no requirement for IL-12
Shimizu et al., J Leukoc Biol 2000
:
While normal
DCs pulsed with the exogenous antigen, keyhole limpet hemocyanin ( KLH )
induced specific Th1-like
interferon-gamma(IFN-gamma) producing CD4+ T cell line, FK-DCs induced Th2-like interleukin-4 (IL-4) producing CD4+ T cell line
Huang et al., Cytokine 2001
:
Correspondingly, IFN-beta treated
DCs strongly
suppressed IFN-gamma production but enhanced IL-10 production by allogeneic blood mononuclear cells
Iwasaki et al., J Immunol 2001
:
Only myeloid
DCs from the PP produce high levels of IL-10 upon
stimulation with soluble CD40 ligand ( - ) trimer, or Staphylococcus aureus and
IFN-gamma
Tabi et al., J Immunol 2001
:
However, we show here that uninfected
DCs induce CD8 ( + ) T cell cytotoxicity and
IFN-gamma production against HCMV pp65 and immediate early 1 Ags following in vitro coculture with HCMV-AD169 infected Fbs, regardless of the HLA type of these FBS : CD8 ( + ) T cell stimulation was inhibited by pretreatment of DCs with cytochalasin B or brefeldin A, indicating a phagosome/endosome to cytosol pathway
Huang et al., Clin Exp Immunol 2001
(Multiple Sclerosis) :
In addition, production of
IFN-gamma by blood mononuclear cells ( MNCs ) was strongly
enhanced by
DCs derived from MS patients
Bellinghausen et al., J Allergy Clin Immunol 2001
(Hypersensitivity, Immediate) :
However, pretreatment of DCs with IL-10 inhibited the production of T ( H ) 1 and T ( H ) 2 cytokines by T cells, whereas HC-treated
DCs inhibited production of
IFN-gamma but induced an increased release of IL-4 and no change in IL-5
Galetto et al., J Surg Res 2001
(Adenocarcinoma...) :
AAT-DCs induced specific
IFN-gamma by T lymphocytes of two patients ( rectal and gastric cancer ), whereas in another two patients ( rectal and gastric cancer ) this response was depressed with a similar tumor-specific pattern and in one patient ( rectal cancer ) there was no response
Yasukawa et al., Blood 2001
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
The bcr-abl b3a2 peptide-specific and HLA-DRB1*0901 restricted CD4+ T-lymphocyte clones produced
interferon-gamma in
response to stimulation with monocyte derived
DCs from HLA-DRB1*0901+ patients with b3a2 type CML
Perez et al., Cancer Immunol Immunother 2002
(Adenocarcinoma...) :
Strong proliferation and significant levels of
IFN-gamma were induced by the CD4 ( + ) T cell clones in
response to specific stimulation with autologous
DCs loaded with HER-2 ( 884-899 )
Ferlazzo et al., J Exp Med 2002
:
The DC-activated NK cells then kill immature DCs efficiently, even though the latter express substantial levels of major histocompatibility complex ( MHC ) class I. Similar results are seen with interleukin (IL)-2 -- activated NK cell lines and clones, i.e., these NK cells kill and secrete
IFN-gamma in
response to immature
DCs
Vuillier et al., Br J Haematol 2001
(Leukemia, Lymphocytic, Chronic, B-Cell) :
Our results demonstrate that : ( 1 ) functional DCs can be generated from CLL patients with similar phenotype and function to those observed from normal donors ; ( 2 ) in contrast to normal control subjects, monocyte derived DCs from CLL patients spontaneously secrete endogenous IL-10 ; and ( 3 )
interferon (IFN)-gamma in combination with CD40L
plays a major role in priming
DCs from CLL patients for IL-12 and IL-15 production
Mailliard et al., J Exp Med 2002
(Influenza, Human...) :
Moreover, the recognition of major histocompatibility complex class I-presented epitopes by antigen-specific CD8+ T cells results in the TNF-alpha- and
IFN-gamma dependent increase in the activation level of
DCs and in the induction of type-1 polarized mature DCs capable of producing high levels of IL-12p70 upon a subsequent CD40 ligation
Strome et al., Cancer Res 2002
(Carcinoma, Squamous Cell...) :
DCs loaded with irradiated tumors were effective stimulators for OT-1 CTLs, whereas
DCs stimulated with freeze thawed or boiled tumors did not
stimulate IFN-gamma production
Langrish et al., Clin Exp Immunol 2002
:
Cord
DCs were also unable to produce IL-12p70, failed to down-regulate expression of the chemokine receptor CCR5 and
induced lower levels of
IFN-gamma production from allogeneic naive CD4+ T cells than their adult counterparts
Fujii et al., Nat Immunol 2002
(Melanoma) :
Prolonged
IFN-gamma producing NKT response
induced with alpha-galactosylceramide loaded
DCs
Hashimoto et al., Infect Immun 2002
:
When a multiplicity of infection of > 40 was used, the
DCs induced a significant proliferative and
IFN-gamma producing response in autologous T cells
Miller et al., Cancer Res 2002
(Lymphoma) :
Infected
DCs markedly
increased allogeneic and antigen-specific T-cell proliferation, and augmented natural killer cell lytic activity and
IFN-gamma production
Ghaemmaghami et al., Clin Exp Allergy 2002
(Hypersensitivity, Immediate) :
Furthermore, we demonstrate that
DCs that have been matured in the presence of proteolytically active Der p 1
induce the production of significantly less
IFN-gamma and more IL-4 by CD4 T cells, compared to DCs that have been matured in the presence of proteolytically inactive Der p 1
Latchumanan et al., J Immunol 2002
:
These
DCs were also potent stimulators of allogeneic T cells and preferentially
induced the secretion of
IFN-gamma over IL-10 from the interacting T cells
Abe et al., Nutrition 2003
(Starvation) :
In particular, liver
DCs from starved mice were unable to
induce interferon-gamma
Calder et al., Scand J Immunol 2003
:
However, stimulation with antigen pulsed
DCs overexpressing IotakappaBetaalpha, the endogenous inhibitor of NF-kappaB,
led to a significant reduction in T-cell proliferation, and decreased production of
interferon-gamma , IL-4 and IL-10, whereas transforming growth factor-beta production was low throughout
Liu et al., Pediatr Res 2003
:
Both non-BCG treated and BCG treated cord blood
DCs efficiently
induced a high level of IL-10, medium level of
interferon-gamma , but little IL-4 production by cord blood naïve CD4+ T cells
Maeda et al., Cell Immunol 2003
:
Moreover these stimulated
DCs induced significantly higher level of
interferon-gamma (IFN-gamma) production by autologous CD4 ( + ) and CD8 ( + ) T cells than those pulsed with equivalent doses of live M. leprae or its cytosol fraction
Heystek et al., Clin Immunol 2003
:
Importantly, IFNalpha/beta strongly counteracted the IL-12 enhancing
effect of
IFN-gamma on
DCs irrespective of their maturation status ... The differential modulatory effect of IFNalpha/beta on the IL-12 producing capacity of
DCs and their cross-regulatory
effect on
IFN-gamma may reduce inflammatory processes and therefore be therapeutically effective in MS
Sorg et al., J Immunother 2003
(Neoplasm Metastasis) :
Mature
DCs effectively clustered with naive T cells and potently
induced allogeneic T-cell proliferation and IL-2 and
IFNgamma but not IL-4 production
Von Stebut et al., J Exp Med 2003
(Disease Models, Animal...) :
Skin-DCs produced significantly less IL-1alpha in
response to
lipopolysaccharide/interferon gamma or L. major when expanded from BALB/c as compared with C57BL/6 mice
Hu et al., Di Yi Jun Yi Da Xue Xue Bao 2003
:
After rAAV-HBsAg infection, the IL-12 secretion of
DCs was significantly
enhanced ( P < 0.05 ), while
IFN-gamma production by the lymphocyte populations co-cultured with rAAV-HbsAg infected DCs was reduced ( P < 0.01 )
Goddard et al., Hematol J 2003
(Leukemia, Lymphocytic, Chronic, B-Cell) :
We have previously shown that autologous
dendritic cells (DCs) pulsed with tumour cell lysate and cultured with autologous T cells from patients with B-cell chronic lymphocytic leukaemia ( B-CLL )
stimulate significant increases in proliferation,
IFN-gamma secretion and specific HLA class II-restricted cytotoxicity to B-CLL targets
Ferreira et al., Scand J Immunol 2003
(Paracoccidioidomycosis) :
It was seen that
DCs from resistant mice
stimulated predominantly interleukin-2 (IL-2) and
interferon-gamma (IFN-gamma) , whereas macrophages activated IL-10, IL-4 and IFN-gamma secreting T cells and B cells IL-4 and IL-10 only
Gervassi et al., J Immunol 2003
:
All five T cell clones secreted
IFN-gamma in
response to autologous
DCs infected with viable Chlamydia, but not with DCs pulsed with inactivated chlamydial elementary bodies
Kuroki et al., Cancer Immunol Immunother 2003
:
IL-12 p70 produced by OK-432 stimulated
imMo-DCs induced secretion of
IFN-gamma by CD4+ T cells
Johansson et al., Scand J Immunol 2004
:
To the contrary, simultaneous
stimulation of control
DCs with 4N1K and LPS +
interferon-gamma did not alter IL-12 production
Wang et al., Blood 2004
:
SARS-CoV protein derived peptide-1 ( SSp-1 RLNEVAKNL ), induced peptide-specific CTLs both in vivo ( transgenic mice ) and in vitro ( human PBLs ), which specifically released
interferon-gamma (IFN-gamma) upon
stimulation with SSp-1 pulsed autologous
dendritic cells (DCs) or T2 cells
Terrazzano et al., Scand J Immunol 2004
:
Our data indicate that CD40 and CD80 molecules might play a preferential role in the induction of cytotoxic function but not in the
interferon-gamma(IFN-gamma) production by human IL-2 activated NK effectors in the
presence of autologous and allogeneic
DCs
Behboudi et al., Cell Immunol 2004
:
In vitro, depletion of CD11c ( + )
DCs from mouse splenocytes, immunised with recombinant vaccinia virus Ankara ( MVA ) expressing pb9 epitope, significantly
reduced the generation of pb9-specific
IFNgamma producing effector CD8 T cells, indicating that splenic DCs are involved in the development of pb9-specific IFNgamma producing effector cells
Liu et al., Br J Haematol 2004
:
In contrast, lipopolysaccharide (LPS) treated adult host
DCs significantly
up-regulated IFN-gamma and down-regulated IL-10 production levels from CB CD4 ( + ) T cells to that from adult blood CD4 ( + ) T cells
Sun et al., Chin Med J (Engl) 2004
(Neoplasms, Experimental) :
DCs transfected with EBV LMP2A recombinant adenovirus could strongly
induce EBV LMP2A-specific cytotoxic T-cell responses and upregulate
interferon-gamma production in vivo
Kamath et al., J Immunol 2005
:
Production of IFN-gamma by NK cells could be stimulated by
DCs from TLR agonist injected mice, and although soluble factors secreted by LPS stimulated DCs were sufficient to induce IFN-gamma, maximal
IFN-gamma production
required both direct contact of NK cells with DCs and DC-secreted cytokines
Shao et al., Genes Immun 2005
(Aspergillosis, Allergic Bronchopulmonary) :
Adoptive transfer of
DCs pulsed with heat inactivated Aspergillus fumigatus ( HAF ) to naive mice
induced the Ag-specific production of
IFN-gamma ; the transduced HAF pulsed DCs augmented this immune response further
Neves et al., Cancer Immunol Immunother 2005
(Carcinoma, Renal Cell...) :
However,
Mo-DCs generated after hybrid cell vaccination presented increased expression of the same markers and
induced significantly higher levels of
IFN-gamma in MLR
Nakahara et al., Clin Exp Immunol 2005
(Neoplasms) :
Our results show that
IFN-gamma + IL-1beta
induced human monocyte derived
DCs to differentiate into Th1-prone mature DCs
Schmitz et al., J Immunol 2005
(Neoplasms) :
We demonstrate that
IFN-gamma stimulated M-DC8 ( + )
DCs lyse different tumor cell lines but not normal cells
Hanada et al., J Immunol 2005
:
SOCS1-deficient
DCs induced higher
IFN-gamma production from naive T cells than wild-type ( WT ) DCs in vitro
Feili-Hariri et al., J Leukoc Biol 2005
:
In contrast, the GM + IL-15
DCs induced higher
IFN-gamma production by T cells with little or no Th2 cytokines
Rathinavelu et al., Helicobacter 2005
(Helicobacter Infections) :
Omp18 primed
DCs induced proliferation and release of
IFNgamma by syngeneic splenocytes
Peng et al., J Immunother 2005
:
When T-cell responses were compared in allogeneic mixed leukocyte reaction,
DCs stimulated with Ribomunyl induced higher levels of
IFNgamma than DCs stimulated with the cytokine cocktail : tumor necrosis factor-alpha, IL-1beta, IL-6, and prostaglandin E2
Van Gulck et al., Blood 2006
(HIV Seropositivity) :
Moreover, hHXB-2 gag mRNA electroporated
DCs also
triggered IFN-gamma secretion by autologous peripheral blood mononuclear cells ( PBMCs ), CD4+ T cells, and CD8+ T cells from all patients tested
Matsue et al., J Immunol 2006
:
LPS- plus
IFN-gamma induced activation of
DCs ( assessed by CD40 expression ) was observed when there was cell-to-cell contact and was significantly blocked by heptanol, a gap junction blocker
Shrestha et al., Ann N Y Acad Sci 2005
:
We observed that TLR-2 stimulated
DCs enhanced
interferon-gamma (IFN-gamma) production by Vdelta2 T cells ; conversely, activated Vdelta2 T cells enhanced TLR-2 induced DC maturation via soluble factors including IFN-gamma, which costimulated interleukin-12 (IL-12) p70 secretion by DCs
Csernok et al., Blood 2006
(Crohn Disease...) :
PR3 maturated
DCs derived from WG patients
induce a higher
IFN-gamma response of PR3-specific CD4 ( + ) T cells compared with patients with CD and healthy controls
Strengell et al., J Leukoc Biol 2006
:
Here, we have analyzed the
effect of IL-21 and
IFN-gamma on lipopolysaccharide (LPS) induced maturation and cytokine production of human monocyte derived
DCs ... In contrast,
IFN-gamma had a positive feedback effect on immature
DCs , and it enhanced LPS induced DC maturation and the production of cytokines
Vaknin-Dembinsky et al., J Immunol 2006
(Multiple Sclerosis) :
Like IL-12, IL-23 is expressed predominantly by activated
dendritic cells (DCs) and phagocytic cells, and both cytokines
induce IFN-gamma secretion by T cells
Kean et al., J Immunol 2006
:
In coculture experiments using the DO11.10 transgenic T cell that recognizes OVA peptide,
DCs exposed to both allergens
induced T cells to produce
IFN-gamma , but only Ber e 1 could induce significant production of IL-4 and IL-5
Chen et al., Biochem Biophys Res Commun 2006
(Neoplasms) :
Further studies revealed that rAd-hTERT transduced
DCs could
increase secretion of
IFN-gamma by effector cells when they were co-cultured with hTERT positive and HLA-A2 matched tumor cell lines
Pepe et al., Curr Pharm Des 2006
:
Dendritic cells (DCs) , instructed by the priming signals from microbial factors, can produce interleukin (IL)-12p70 and
promote T helper ( Th ) 1 proliferation and
interferon (IFN)-gamma production
Mitchell et al., Infect Immun 2007
(Helicobacter Infections) :
We also demonstrated that
DCs treated with H. pylori
induced IFN-gamma production by allogeneic naive T cells
Kvale et al., Blood 2007
:
In contrast, CD11c ( + )
DCs induce
IFN-gamma and little IL-10
Moore et al., Infect Immun 2007
:
Depletion of monocytes revealed that they were the primary source of inflammatory cytokines, while
dendritic cells (DCs) directed
IFN-gamma production from innate lymphocytes
Chen et al., Stem Cells Dev 2006
:
DCs matured in the presence of both LPA and LPS
enhanced the production of
interferon-gamma (IFN-gamma) when co-cultured with allogeneic T cells, compared with DC matured by LPS alone
Jeong et al., Biochem Biophys Res Commun 2007
:
Based on our results, this study may account that EGCG could inhibit IDO expression by down-regulation of STAT1 activation and COX-2 expression in
IFN-gamma stimulated murine
DCs
Ceballos et al., Immunology 2007
:
SPC increased the expression of HLA-DR, CD86 and CD83 and improved the T-cell priming ability of
DCs , as well as the ability of DCs to
stimulate the production of
interferon-gamma by allogeneic peripheral blood mononuclear cells during the mixed lymphocyte reaction
Kim et al., Int Immunopharmacol 2007
(Melanoma, Experimental) :
Based on our results, this study may account that CA could inhibit IDO expression by down-regulation of STAT1 activation in
IFN-gamma stimulated murine
DCs
Johansson et al., J Immunol 2007
(Necrosis) :
Furthermore, we show that
DCs exposed to allogeneic, activated apoptotic PBMCs
induce proliferation and
IFN-gamma production in autologous T cells
Liu et al., J Huazhong Univ Sci Technolog Med Sci 2007
:
Compared with the DC2.4 cells and the LPS-DC, the
T-DCs inhibited alloactivated T cell proliferation and
down-regulated the
IFN-gamma secretion in MLR supernatant
Tha-In et al., Blood 2007
:
In the present study, we showed that DCs matured in the
presence of IVIgs (
IVIg-DCs ) activated NK cells, and increased their
interferon-gamma production and degranulation
Maeda et al., Immunobiology 2007
:
Pretreatment of DCs with IL-21 and alpha-galactosylceramide ( alpha-GalCer ), an NKT cell-specific ligand, resulted in the enhanced ability of the
DCs to
induce NKT cell production of
IFN-gamma but not IL-4 in vitro compared to DCs pretreated with alpha-GalCer alone
Zhang et al., Cell Immunol 2007
(Carcinoma, Hepatocellular...) :
Additionally,
DCs pulsed with the chimeric HBc-VLPs could
induce stronger CTL activity and greater
IFN-gamma secretion by responding T cells compared with peptid pulsed DCs
Cai et al., Tumour Biol 2007
(Stomach Neoplasms) :
Meanwhile, these rAd-Hpa modified
DCs could
increase IFN-gamma secretion of effector cells when cocultured with KATO-III cells
Fujii et al., Immunol Rev 2007
(Neoplasms) :
We compared administration of alpha-GalCer on mature DCs with soluble glycolipid and found that
DCs induced more prolonged
interferon-gamma (IFN-gamma) production by NKT cells and better protection against B16 melanoma
Wang et al., J Immunol 2007
:
When cocultured with purified NK cells, WSX-1-deficient
DCs induced higher
IFN-gamma production and killing activity of NK cells than wild-type DCs
Mascanfroni et al., FASEB J 2008
:
Remarkably, physiological levels of triiodothyronine ( T3 ) stimulated the expression of DC maturation markers ( major histocompatibility complex II, CD80, CD86, and CD40 ), markedly increased the secretion of interleukin-12, and stimulated the ability of
DCs to
induce naive T cell proliferation and
IFN-gamma production in allogeneic T cell cultures
Salazar et al., Ann Rheum Dis 2008
(Arthritis, Experimental...) :
Co-cultures of DCs with splenocytes from CIA mice showed that collagen-specific
interferon (IFN)gamma production was dramatically
inhibited by
4hLPS/CII/DCs
Scordamaglia et al., J Allergy Clin Immunol 2008
(Respiratory Hypersensitivity) :
This was reflected by reduced NK cell mediated
IFN-gamma production in
response to
DCs
Scholz et al., J Am Soc Nephrol 2008
(Glomerulonephritis) :
In ex vivo coculture experiments with antigen-specific CD4 ( + ) T cells,
DCs stimulated the secretion of IL-10, which is known to attenuate nephrotoxic nephritis, and the Th1 cytokine
IFNgamma
Kim et al., J Immunol 2008
:
AIMP1 stimulated
DCs significantly
enhanced the
IFN-gamma production of cocultured CD4+ T cells
Hegde et al., J Leukoc Biol 2008
:
Also, CD44-deficient
DCs induced significantly decreased proliferation as well as IL-2 and
IFN-gamma production from allogeneic T cells
Ni et al., J Invest Dermatol 2008
(Sezary Syndrome...) :
The
induction of antitumor
IFN-gamma and granzyme B (GrB) producing cytotoxic T lymphocytes ( CTL ) by RNA transfected
DCs was determined by ELISPOT assays
Koizumi et al., Immunol Lett 2008
:
S-PT84
induced IFN-gamma producing cells through activation of IL-12 production by CD11c ( + )
DCs in Toll-like receptor (TLR) 2- and/or TLR4 dependent manner ... Interestingly, direct interaction between
DCs and NK1.1 ( + ) cells was also
essential for the
IFN-gamma production in response to the S-PT84 stimulation
Lombardi et al., Clin Exp Allergy 2008
(Asthma...) :
Only Pam3CSK4 treated
DCs induce
IFN-gamma and IL-10 secretion by naïve CD4 ( + ) T cells
Price et al., Immunology 2009
(Tuberculosis, Bovine) :
Dendritic cells (DCs) are capable of secreting high levels of interleukin-12 (IL-12) following infection with mycobacteria and can
induce interferon-gamma (IFN-gamma) secretion by natural killer and gammadelta T cells We investigated the innate interactions occurring between WC1 ( + ) gammadelta T cells and M. bovis infected DCs
Leibundgut-Landmann et al., Blood 2008
:
In vitro but not in vivo, CTL crosspriming was dependent on IL-12 p70, which was produced by dectin-1 activated
DCs in
response to
IFN-gamma secreted by newly activated CD8 ( + ) T cells
Tada et al., Arthritis Res Ther 2008
(Arthritis, Experimental...) :
The
DCs from RP105-deficient mice
induced more
IFN-gamma production, whereas Tregs from those mice showed less inhibitory effect against IFN-gamma production
Wang et al., Zhongguo Shi Yan Xue Ye Xue Za Zhi 2008
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
PD-L1 blockaded
DCs could enhance T lymphocyte proliferation,
increase the secretion of IL-2 and
IFN-gamma , and inhibit the production of IL-10
Sato et al., Cytotechnology 2002
:
We investigated the
role of Peyer 's patch ( PP )
dendritic cells (DCs) in the production of
interferon (IFN)-gamma from naïve CD4 ( + ) T cells of T cell receptor transgenic mice ... This data demonstrates that PP DCs have a distinct function in the induction of IFN-gammas and suggests that PP
DCs may
enhance IFN-gamma production via another cytokine or costimulatory molecule, in addition to IL-12
Hibi et al., Cytotechnology 2003
:
DCs from each tissue induced IL-4 secretion from naive CD4 ( + ) T cells in the presence of low dose antigenic peptide, and
induced IFN-gamma production at high doses of antigen ... In conclusion,
DCs from SPL, MLN and PP can
induce the production of both IL-4 and
IFN-gamma from naive CD4 ( + ) T cells, depending on antigen dose ... MLN derived CD11c ( + ) /B220 ( - )
DCs induce higher
IFN-gamma production from naive CD4 ( + ) T cells than SPL derived DCs, through efficient IL-12 secretion
Jeong et al., J Biol Chem 2009
(Neoplasms) :
Indoleamine 2,3-dioxygenase (IDO) catalyzes the initial and rate limiting step in the degradation of tryptophan and is strongly induced in
interferon-gamma (IFNgamma) stimulated
dendritic cells (DCs)
Kassim et al., J Virol 2009
(Herpes Simplex) :
Overall, this study provides direct evidence that functional
DCs are
required for optimal
IFN-gamma expression and cytolytic function by NK cells following infection with HSV-1
Hegde et al., J Leukoc Biol 2009
:
The control
DCs efficiently
stimulated peripheral blood T cell
IFN-gamma secretion and proliferation, whereas NKT instructed APCs silenced these T cell responses
Wong et al., J Immunol 2009
:
IL-12p70 production was produced predominantly by CD8alpha ( + )
DCs and plasmacytoid DCs, and
mediated by CD8 T cell derived cytokines
IFN-gamma , GM-CSF, TNF-alpha, and surface CD40L
Liu et al., Zhonghua Yi Xue Za Zhi 2009
(Asthma...) :
The
IFN-gamma level in the culture fluid of the T-bet gene modified DCs was ( 15.24 +/- 4.75 ) ng/ml, significantly higher than that of the LacZ gene modified DCs and
control DCs [ ( 3.08 +/- 0.61 ) and ( 2.35 +/- 0.41 ) ng/ml respectively, both P < 0.01 ]
Kayama et al., PLoS Pathog 2009
(Calcium Signaling...) :
T. cruzi infected Nfatc1 ( -/- ) fetal liver
DCs were
impaired in
IFN-gamma production and DC maturation
Tam et al., Immunology 2009
(Listeriosis) :
We found that
DCs from Listeria infected MyD88 ( -/- ) and MyD88 ( -/- ) IFN-alphabetaR ( -/- ) mice
induced little or no
IFN-gamma by CD8 T cells, respectively
Liu et al., World journal of pediatrics : WJP 2010
:
Moreover, in comparison with BCG treated adult blood DCs, BCG treated CB
DCs induced higher IL-10 production and cytotoxic T-lymphocyte antigen 4 ( CTLA-4 ) expression, and lower
interferon-gamma (IFN-gamma) production from naïve CD4+ T cells
Terrazas et al., Int J Parasitol 2010
:
DCs pulsed with TcES+OVA
suppressed IFN-gamma , whereas they induced greater IL-4 production by CD4 ( + ) DO11.10 cells
Shao et al., Cell Immunol 2010
:
Two peptides of CKLF1, C19 and C27, stimulated the
effect of immature
DCs ( imDCs ) on T-cell proliferation and
IFN-gamma production
Pochard et al., J Allergy Clin Immunol 2010
(Peanut Hypersensitivity) :
Peanut pulsed
DCs induced the production of IL-4, IL-5, and IL-13, as well as IL-17 and
IFN-gamma , from primed T cells
Masuda et al., Cancer Immunol Immunother 2010
(Colonic Neoplasms) :
MZF treated
DCs significantly
stimulated both allogeneic and antigen-specific syngenic T cell responses and enhanced antigen-specific
interferon-gamma (IFN-gamma) production by syngenic CD4 ( + ) T cells ; however, MZF treated DCs did not affect IL-4 production ... Furthermore, the enhancement of
IFN-gamma production in CD4 ( + ) T cells, which was
induced by MZF treated
DCs , was completely inhibited by the addition of an anti-IL-12 antibody
Downing et al., Br J Biomed Sci 2012
:
Aspirin-, dexamethasone- VD3- and butyric acid modified
DCs suppressed
interferon-gamma production, proliferation and cytotoxicity in co-culture with allogeneic mononuclear cells, but inconsistent results were obtained with different allogeneic combinations
Cella et al., J Exp Med 1996
:
These effects of CD40 ligation
result in an increased capacity of
DCs to trigger proliferative responses and
IFN-gamma production by T cells