Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
PDPK1
→
IGF1
(increases, IGF1 Activity)
Rena et al., EMBO J 2002 Evidence: IGF-1 stimulates the phosphorylation of Thr24, Ser256, Ser319, Ser322 and Ser325 in embryonic stem (ES) cells, but not in PDK1-/- ES cells, providing genetic evidence that PDK1 (the upstream activator of PKB) is required for the phosphorylation of FKHR in mammalian cells.