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IL8 — NOD2

Text-mined interactions from Literome

Uehara et al., Cell Microbiol 2005 : Suppression of the mRNA expression of nucleotide binding oligomerization domain ( NOD)1 and NOD2 by RNA interference specifically inhibited the synergistic IL-8 secretion induced by DMP and MDP with these TLR agonists respectively
Takada et al., Curr Pharm Des 2006 : In human monocytic cells, both MDP and DMPs exhibited definite activities ; marked synergistic interleukin (IL)-8 secretion was induced by DMPs and MDP in combination with synthetic TLR agonists, and suppression of the mRNA expressions of NOD1 and NOD2 , respectively, by RNA interference specifically inhibited synergistic IL-8 secretion
Uehara et al., Mol Immunol 2007 : Anti-RP3 Abs markedly promoted the release of IL-8 induced by chemically synthesized TLR and NOD ligands mimicking bacterial components : TLR2-agonistic lipopeptide ( FSL-1 ), TLR3-agonistic poly I:C, TLR4-agonistic lipid A ( LA-15-PP ), TLR7/8-agonistic single stranded RNA ( ssPolyU ), TLR9-agonistic bacterial CpG DNA, NOD1-agonistic FK156/565 and NOD2-agonistic muramyldipeptide ( MDP ) in THP-1 cells and human peripheral blood mononuclear cells, although sole incubation with anti-PR3 Abs induced only a low level of IL-8
Gandotra et al., Infect Immun 2007 (Tuberculosis) : Mycolylarabinogalactan peptidoglycan ( PGN ), the cell wall core of M. tuberculosis, stimulated macrophages to release tumor necrosis factor (TNF) and interleukin-12p40 in a partially NOD2 dependent manner, and M. tuberculosis PGN required NOD2 for the optimal induction of TNF
Ekman et al., Immunology 2010 : NOD2 activation with MurNAc-l-Ala-d-isoGln ( MDP ) resulted in interleukin-8 secretion, CD62 ligand down-regulation, CD11b up-regulation and increased migration towards an inflammatory stimulus
Lecat et al., J Biol Chem 2012 : This interaction attenuates NOD2 mediated NF-?B activation and IL-8 secretion as well as NOD2 antibacterial activity
Swain et al., J Biosci 2013 (Bacterial Infections) : In response to both Gram positive and Gram negative bacterial infections, NOD1 and NOD2 receptors signalling were activated and IL-1 beta, IL-8 and IFN- gamma were induced