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EPX — MAPK3
Text-mined interactions from Literome
Sui et al., Br J Haematol 2000
:
We have recently demonstrated that SCF and
EPO synergistically
activate mitogen activated protein ( MAP ) kinase , thereby promoting growth of human erythroid colony forming cells ( ECFCs )
Zhande et al., Am J Physiol Heart Circ Physiol 2007
:
EPO also
activates extracellular signal regulated kinase 1 and 2 ( ERK1/2 ), which are involved in a Bcl-x ( L ) -independent cytoprotective pathway
Jeong et al., Int J Cancer 2008
(Ovarian Neoplasms) :
The EpoR on A2780 cells was shown to be functional, since
Epo stimulation
resulted in phosphorylation of
Erk1/2 , an important EpoR mitogenic signaling intermediate
Lee et al., Cancer Res 2011
(Lymphatic Metastasis...) :
These effects were abrogated by cotreatment with specific inhibitors of phosphoinositide 3-kinase or mitogen activated protein kinase, under conditions in which
EPO increased Akt and
extracellular signal regulated kinase 1/2 phosphorylation
Klingmüller et al., Eur J Biochem 1997
:
The signal emanating from Y479 involves sequential
EPO induced recruitment of phosphoinositol lipid 3-kinase to the EPO-R and activation of
mitogen-activated-protein ( MAP ) kinase activity
Sui et al., Blood 1998
:
Together, the data suggest that synergistic
activation of
MAPK by SCF and
EPO is essential for expanded erythropoiesis