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RAC1 — TGFB1
Text-mined interactions from Literome
Han et al., J Clin Invest 2005
(Carcinoma in Situ...) :
However, Delta ( beta ) RII did not alter
TGF-beta1 mediated expression of
RhoA/Rac and MAPK, which contributed to increased metastasis
Varon et al., Exp Cell Res 2006
:
Thus,
Rac1 and RhoA are
regulated by
TGFbeta1 in the process of endothelial tube formation in collagen I gels
Hubchak et al., American journal of physiology. Renal physiology 2009
(Fibrosis) :
TGF-beta1 activated both RhoA and
Rac1 within 5 min of treatment, and this activation was dependent on the kinase activity of the type I TGF-beta receptor ... Furthermore, the PI3K antagonist, LY294002, reduced
TGF-beta1 stimulated COL1A2 promoter activity and
Rac1 activation ... Thus, while both
Rac1 and RhoA are rapidly activated in
response to
TGF-beta1 in human mesangial cells, only Rac1 activation enhances events that contribute to mesangial cell collagen expression, through a positive feedback loop involving PI3K
Vivien et al., J Cell Physiol 1993
:
We previously showed that
TGF-beta 1 increased DNA replication rate of
RAC , with a recruitment of cells in G2/M followed by a subsequent mitosis wave