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PPARG — SCARB1

Text-mined interactions from Literome

Chinetti et al., Circulation 2000 (Arteriosclerosis) : Activation of PPARalpha and PPARgamma resulted in the induction of CLA-1 protein expression in monocytes and in differentiated macrophages
Malerød et al., Biochem Biophys Res Commun 2003 : We found in the present study that PPARgamma induces expression of SR-BI in rat hepatocytes, liver endothelial cells, and Kupffer cells ... Furthermore, hepatocyte nuclear factor 4alpha ( HNF4alpha ) was found to enhance PPARgamma mediated SR-BI transcription ... Thiazolidinedione ( TZD ) -activated PPARgamma/RXR increased hepatic SR-BI levels, which may lead to increased hepatic cholesterol uptake and less accumulation of lipids in peripheral tissues
Westendorf et al., Mol Cell Biochem 2005 : Using the highly sensitive real-time RT-PCR we could demonstrate that HOCl-LDL upregulated CD36 and PPARgamma levels dose- and time dependently while modulating SR-BI message levels differently in dependence on HOCl-LDL concentration and incubation time
Ahmed et al., Endocrine 2009 (Carcinoma, Hepatocellular...) : In this study, we examined the effects of thiazolidinedione PPAR-gamma on hepatic SR-B1 gene expression in human hepatoma G2 cell-line ( HepG2 ) ... PPAR-gamma and RXR sufficiently induced the SR-B1 promoter activity in the HepG2 cells ... Together, these results indicate that the stimulation of SR-B1 expression in the liver is mediated in part by activation of the PPAR-gamma and RXR, and raise the possibility that this stimulation using thiazolidinediones conditions provides a protective mechanism for accelerated atherosclerosis in diabetes mellitus