Campana et al., J Neurosci 2006
(Sciatic Neuropathy) :
Silencing of Schwann cell LRP-1 with siRNA decreased phosphorylated Akt and increased activated caspase-3 Fuentealba et al., J Biol Chem 2009
(Neurodegenerative Diseases) :
Using lentiviral short hairpin RNA to knock down endogenous LRP1 expression, we showed that a depletion of LRP1 leads to an activation of caspase-3 and increased neuronal apoptosis, an effect that was rescued by a caspase-3 inhibitor