Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
PLCB1
→
F2
(increases, F2 Activity, PLCB1 Activity)
Evidence: 13,50-52 In the case of some of these agonists, one consequence important for inside-out signaling is activation of phospholipase C-beta by the activated alpha subunit of Gq, resulting in hydrolysis of phosphatidylinositol and production of the second messengers, diacylglycerol and IP3. Mouse platelets that have been rendered null for Gq undergo shape change but fail to aggregate in response to thrombin, ADP, or a thromboxane A2 receptor agonist, and the mice exhibit prolonged tail bleeding time...