Schmidt et al., J Immunol 2006
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We demonstrate that Btk is activated by TLR4 in primary macrophages and is required for normal TLR induced IL-10 production in multiple macrophage populations
Contreras et al., Mol Immunol 2007
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We also show that Btk mediates the survival of, and expression of IL-10 by, those B-1 cells that do develop and migrate to the peritoneum
Lee et al., J Biol Chem 2008
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Thus, Btk plays an important role in TLR9 signaling and acts separately to regulate NFkappaB RelA activation as well as IL-10 and IL-12 production in B cells
Singhal et al., J Biol Chem 2011
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Furthermore, we provide the first evidence that HGF inhibits DC activation by inducing autocrine interleukin (IL)-10 secretion, which requires activation of Btk ... Blocking activation of Btk and its downstream the c-Src-PI3K-AKT-mTOR pathway prevents HGF induced IL-10 secretion by DCs