◀ Back to TGFB3
TGFB3 — TGFBR1
Pathways - manually collected, often from reviews:
-
BioCarta tgf beta signaling pathway:
TGF-beta/TGF-beta R1 complex (TGFB1_TGFB2_TGFB3-TGFBR1)
→
TGF-beta (TGFB1/TGFB2/TGFB3)
(modification, collaborate)
-
BioCarta tgf beta signaling pathway:
TGF-beta/TGF-beta R1 complex (TGFB1_TGFB2_TGFB3-TGFBR1)
→
TGF-beta-R1 (TGFBR1)
(modification, collaborate)
-
BioCarta tgf beta signaling pathway:
TGF-beta (TGFB1/TGFB2/TGFB3)
→
TGF-beta-R1 (TGFBR1)
(modification, collaborate)
-
BioCarta ctcf: first multivalent nuclear factor:
TGF-beta/TGF-beta-R1/TGF-beta-R2 complex (TGFB1_TGFB2_TGFB3-TGFBR2-TGFBR1)
→
TGF-beta/TGF-beta/TGF-beta-R1/TGF-beta-R1/TGF-beta-R2/TGF-beta-R2 complex (TGFB1_TGFB2_TGFB3-TGFBR2-TGFBR1)
(modification, collaborate)
-
BioCarta tgf beta signaling pathway:
MADH7 (SMAD7)
→
TGF-beta/TGF-beta/TGF-beta-R1/TGF-beta-R1/TGF-beta-R2/TGF-beta-R2 complex (TGFB1_TGFB2_TGFB3-TGFBR2-TGFBR1)
(modification, inhibits)
-
BioCarta tgf beta signaling pathway:
SMAD2/SARA complex (SAR1A-SMAD2)
→
TGF-beta/TGF-beta/TGF-beta-R1/TGF-beta-R1/TGF-beta-R2/TGF-beta-R2 complex (TGFB1_TGFB2_TGFB3-TGFBR2-TGFBR1)
(modification, collaborate)
-
BioCarta nfkb activation by nontypeable hemophilus influenzae:
TGF-beta/TGF-beta-R1/TGF-beta-R2 complex (TGFB1_TGFB2_TGFB3-TGFBR2-TGFBR1)
→
TGF-beta (TGFB1/TGFB2/TGFB3)
(modification, collaborate)
-
BioCarta nfkb activation by nontypeable hemophilus influenzae:
TGF-beta/TGF-beta-R1/TGF-beta-R2 complex (TGFB1_TGFB2_TGFB3-TGFBR2-TGFBR1)
→
TGF-beta-R1/TGF-beta-R2 complex (TGFBR1-TGFBR2)
(modification, collaborate)
-
BioCarta nfkb activation by nontypeable hemophilus influenzae:
TGF-beta (TGFB1/TGFB2/TGFB3)
→
TGF-beta-R1/TGF-beta-R2 complex (TGFBR1-TGFBR2)
(modification, collaborate)
-
BioCarta ctcf: first multivalent nuclear factor:
TGF-beta/TGF-beta R1 complex (TGFB1_TGFB2_TGFB3-TGFBR1)
→
TGF-beta/TGF-beta-R1/TGF-beta-R2 complex (TGFB1_TGFB2_TGFB3-TGFBR2-TGFBR1)
(modification, collaborate)
-
BioCarta ctcf: first multivalent nuclear factor:
TGF-beta/TGF-beta R1 complex (TGFB1_TGFB2_TGFB3-TGFBR1)
→
TGF-beta-R2 (TGFBR2)
(modification, collaborate)
-
BioCarta ctcf: first multivalent nuclear factor:
TGF-beta/TGF-beta-R1/TGF-beta-R2 complex (TGFB1_TGFB2_TGFB3-TGFBR2-TGFBR1)
→
TGF-beta-R2 (TGFBR2)
(modification, collaborate)
-
BioCarta alk in cardiac myocytes:
TGF-beta/TGF-beta-R1/TGF-beta-R2 complex (TGFB1_TGFB2_TGFB3-TGFBR2-TGFBR1)
→
TGF-beta (TGFB1/TGFB2/TGFB3)
(modification, collaborate)
-
BioCarta alk in cardiac myocytes:
TGF-beta/TGF-beta-R1/TGF-beta-R2 complex (TGFB1_TGFB2_TGFB3-TGFBR2-TGFBR1)
→
TGF-beta-R1 (TGFBR1)
(modification, collaborate)
-
BioCarta alk in cardiac myocytes:
TGF-beta/TGF-beta-R1/TGF-beta-R2 complex (TGFB1_TGFB2_TGFB3-TGFBR2-TGFBR1)
→
TGF-beta-R2 (TGFBR2)
(modification, collaborate)
-
BioCarta alk in cardiac myocytes:
TGF-beta (TGFB1/TGFB2/TGFB3)
→
TGF-beta-R1 (TGFBR1)
(modification, collaborate)
-
BioCarta ctcf: first multivalent nuclear factor:
TGF-beta/TGF-beta R1 complex (TGFB1_TGFB2_TGFB3-TGFBR1)
→
TGF-beta (TGFB1/TGFB2/TGFB3)
(modification, collaborate)
-
BioCarta ctcf: first multivalent nuclear factor:
TGF-beta/TGF-beta R1 complex (TGFB1_TGFB2_TGFB3-TGFBR1)
→
TGF-beta-R1 (TGFBR1)
(modification, collaborate)
-
BioCarta ctcf: first multivalent nuclear factor:
TGF-beta (TGFB1/TGFB2/TGFB3)
→
TGF-beta-R1 (TGFBR1)
(modification, collaborate)
-
BioCarta tgf beta signaling pathway:
TGF-beta/TGF-beta-R1/TGF-beta-R2 complex (TGFB1_TGFB2_TGFB3-TGFBR2-TGFBR1)
→
TGF-beta/TGF-beta/TGF-beta-R1/TGF-beta-R1/TGF-beta-R2/TGF-beta-R2 complex (TGFB1_TGFB2_TGFB3-TGFBR2-TGFBR1)
(modification, collaborate)
-
BioCarta tgf beta signaling pathway:
MADH7 (SMAD7)
→
TGF-beta/TGF-beta/TGF-beta-R1/TGF-beta-R1/TGF-beta-R2/TGF-beta-R2 complex (TGFB1_TGFB2_TGFB3-TGFBR2-TGFBR1)
(modification, inhibits)
-
BioCarta nfkb activation by nontypeable hemophilus influenzae:
TGF-beta/TGF-beta-R1/TGF-beta-R2 complex (TGFB1_TGFB2_TGFB3-TGFBR2-TGFBR1)
→
SMAD3
(modification, activates)
-
BioCarta tgf beta signaling pathway:
TAB1 (MAP3K7IP1)
→
TGF-beta/TGF-beta/TGF-beta-R1/TGF-beta-R1/TGF-beta-R2/TGF-beta-R2 complex (TGFB1_TGFB2_TGFB3-TGFBR2-TGFBR1)
(modification, collaborate)
-
BioCarta tgf beta signaling pathway:
NR2C2
→
TGF-beta/TGF-beta/TGF-beta-R1/TGF-beta-R1/TGF-beta-R2/TGF-beta-R2 complex (TGFB1_TGFB2_TGFB3-TGFBR2-TGFBR1)
(modification, collaborate)
-
BioCarta tgf beta signaling pathway:
TGF-beta/TGF-beta R1 complex (TGFB1_TGFB2_TGFB3-TGFBR1)
→
TGF-beta/TGF-beta-R1/TGF-beta-R2 complex (TGFB1_TGFB2_TGFB3-TGFBR2-TGFBR1)
(modification, collaborate)
-
BioCarta tgf beta signaling pathway:
TGF-beta/TGF-beta R1 complex (TGFB1_TGFB2_TGFB3-TGFBR1)
→
TGF-beta-R2 (TGFBR2)
(modification, collaborate)
-
BioCarta tgf beta signaling pathway:
TGF-beta/TGF-beta-R1/TGF-beta-R2 complex (TGFB1_TGFB2_TGFB3-TGFBR2-TGFBR1)
→
TGF-beta-R2 (TGFBR2)
(modification, collaborate)
-
KEGG MAPK signaling pathway:
TGFB1/TGFB2/TGFB3
→
TGFBR1/TGFBR2
(protein-protein, activation)
-
KEGG Pathways in cancer:
TGFB1/TGFB2/TGFB3
→
Complex of TGFBR1-TGFBR2
(protein-protein, activation)
-
KEGG Pancreatic cancer:
TGFB1/TGFB2/TGFB3
→
Complex of TGFBR1-TGFBR2
(protein-protein, activation)
-
KEGG Chronic myeloid leukemia:
TGFB1/TGFB2/TGFB3
→
Complex of TGFBR1-TGFBR2
(protein-protein, activation)
-
KEGG Cytokine-cytokine receptor interaction:
TGFB3
→
Complex of TGFBR1-TGFBR2
(protein-protein, activation)
-
NCI Pathway Database ALK1 signaling events:
TGFB3/TGFBR2/Endoglin/TGFBR1/ALK1 complex (TGFBR2-TGFBR1-ACVRL1-ENG-TGFB3)
→
SMAD1-5-8 (SMAD1/SMAD9/SMAD5)
(modification, activates)
Oh et al., Proc Natl Acad Sci U S A 2000, Goumans et al., EMBO J 2002, Goumans et al., Mol Cell 2003
Evidence: mutant phenotype, assay
-
NCI Pathway Database Glypican 1 network:
TGFB family (dimer) (TGFB3/TGFB1)
→
TGFBR1 (dimer) complex (TGFBR1)
(modification, collaborate)
Li et al., Biochem Biophys Res Commun 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database Glypican 1 network:
TGFB family (dimer) (TGFB3/TGFB1)
→
GPC1/TGFB/TGFBR1/TGFBR2 complex (TGFBR1-GPC1-TGFBR2)
(modification, collaborate)
Li et al., Biochem Biophys Res Commun 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database ALK1 signaling events:
TGFB3/TGFBR2/Endoglin/TGFBR1/ALK1 complex (TGFBR2-TGFBR1-ACVRL1-ENG-TGFB3)
→
FKBP12 (FKBP1A)
(modification, collaborate)
Lux et al., J Biol Chem 1999, Goumans et al., Mol Cell 2003, Wang et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ALK1 signaling events:
TGFB3/TGFBR2/Endoglin/TGFBR1/ALK1 complex (TGFBR2-TGFBR1-ACVRL1-ENG-TGFB3)
→
FKBP12/TGFBR1 (dimer) complex (TGFBR1-FKBP1A)
(modification, collaborate)
Lux et al., J Biol Chem 1999, Goumans et al., Mol Cell 2003, Wang et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ALK1 signaling events:
TGFB3/TGFBR2/Endoglin/TGFBR1/ALK1 complex (TGFBR2-TGFBR1-ACVRL1-ENG-TGFB3)
→
FKBP12/ALK1 (dimer) complex (FKBP1A-ACVRL1)
(modification, collaborate)
Lux et al., J Biol Chem 1999, Goumans et al., Mol Cell 2003, Wang et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ALK1 signaling events:
TGFB3/TGFBR2/Endoglin/TGFBR1/ALK1 complex (TGFBR2-TGFBR1-ACVRL1-ENG-TGFB3)
→
TGFB3/TGFBR2/Endoglin (dimer) complex (TGFBR2-ENG-TGFB3)
(modification, collaborate)
Lux et al., J Biol Chem 1999, Goumans et al., Mol Cell 2003, Wang et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ALK1 signaling events:
FKBP12/TGFBR1 (dimer) complex (TGFBR1-FKBP1A)
→
TGFB3/TGFBR2/Endoglin (dimer) complex (TGFBR2-ENG-TGFB3)
(modification, collaborate)
Lux et al., J Biol Chem 1999, Goumans et al., Mol Cell 2003, Wang et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
-
WikiPathways Extracellular vesicle-mediated signaling in recipient cells:
TGFB1/TGFB2/TGFB3
→
TGFBR1/TGFBR3
(activation)
-
WikiPathways MAPK Signaling Pathway:
TGFB2/TGFB1/TGFB3
→
ACVR1C/ACVR1B/TGFBR1/TGFBR2
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
TGFB3
—
TGFBR1
Lin et al., J Biol Chem 1995
-
IRef Bind_translation Interaction:
TGFB3
—
TGFBR1
(competition binding)
Lin et al., J Biol Chem 1995
-
MIPS CORUM TGF-beta receptor II-TGF-beta receptor I-TGF-beta3 complex:
TGF-beta receptor II-TGF-beta receptor I-TGF-beta3 complex complex (TGFB3-TGFBR1-TGFBR2)
Zúñiga et al., J Mol Biol 2005*
-
IRef Dip Interaction:
TGFB3
—
TGFBR1
(physical association, biochemical)
Lux et al., J Biol Chem 1999
-
IRef Hprd Interaction:
TGFBR1
—
TGFB3
(in vivo)
Hart et al., Nat Struct Biol 2002*, Jude et al., Diabet Med 2002*, Saed et al., Am J Reprod Immunol 2002*
-
IRef Intact Interaction:
Complex of 19 proteins
(physical association, surface plasmon resonance)
Huang et al., EMBO J 2011*
-
IRef Ophid Interaction:
TGFB3
—
TGFBR1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
-
IRef Ophid Interaction:
TGFB3
—
TGFBR1
(aggregation, confirmational text mining)
Text-mined interactions from Literome
Franchi et al., Applied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry 2001
(Bone Neoplasms...) :
Transforming growth factor-beta2 and
TGF-beta3 were
detected in the majority of cases ( 97.1 % and 82.8 %, respectively ), whereas
TGF-beta receptor type I ( TGF-beta RI ) and type II ( TGF-beta RII ) were diffusely expressed in all cases
Matsuzaki et al., Hepatology 2007
(Carcinoma, Hepatocellular...) :
Conversely,
transforming growth factor beta ( TGF-beta )
activates not only
TGF-beta type I receptor ( TbetaRI ) but also c-Jun N-terminal kinase (JNK), which convert the mediator Smad3 into two distinctive phosphoisoforms : C-terminally phosphorylated Smad3 ( pSmad3C ) and linker phosphorylated Smad3 ( pSmad3L )
Alfranca et al., Blood 2008
:
MT1-MMP dependent
transforming growth factor beta ( TGFbeta ) signaling through Alk5 is also required for PGE ( 2 ) -induced endothelial cord formation in vitro, and
Alk5 kinase activity is
required for PGE ( 2 ) -induced neovascularization in vivo