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FGF2 — TP53

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: FGF2 → TP53 (decreases)
  Evidence: The sentence (ResnetDB) Tumour suppressor p53 has been shown to inhibit fibroblast growth factor 2 expression post-transcriptionally in cultured cells. is translated to Inhibition of FGF2 (Homo sapiens) Gene Expression by TP53 (Homo sapiens) Protein The following edits have been made already none Links Doc Sourcerer for 11498784 TP53 (Homo sapiens) Protein FGF2 (Homo sapiens) Gene Expression

Text-mined interactions from Literome

Galy et al., Oncogene 2001 (Neoplasms) : Tumour suppressor p53 inhibits human fibroblast growth factor 2 expression by a post-transcriptional mechanism ... Transient cell transfection revealed an inhibitory effect of wild-type p53 on the expression of chimeric FGF -- CAT proteins ... RNAse mapping experiments ruled out any effect of p53 on FGF -- CAT mRNA accumulation, suggesting a translational inhibition
Galy et al., Oncogene 2001 : Tumour suppressor p53 has been shown to inhibit fibroblast growth factor 2 expression post-transcriptionally in cultured cells
Ashton et al., Circ Res 2004 (Inflammation...) : The deficit in FGFR1 internalization was mediated through activation of TPbeta preventing the FGF-2 mediated decrease in p53 expression, thus enhancing thrombospondin-1 (TSP-1) release from EC and reducing FGFR1 internalization
Romanov et al., Oncogene 2005 (Leukemia, Lymphocytic, Chronic, B-Cell) : Basic fibroblast growth factor suppresses p53 activation in the neoplastic cells of a proportion of patients with chronic lymphocytic leukaemia
Jin et al., Exp Mol Med 2010 : Furthermore, loss of TERT or bFGF markedly increases a p53 activity and DNA-damage sensitivity in HFFS, HeLa and U87MG cells
Ueba et al., Proc Natl Acad Sci U S A 1994 (Carcinoma, Hepatocellular...) : Transcriptional regulation of basic fibroblast growth factor gene by p53 in human glioblastoma and hepatocellular carcinoma cells ... Therefore, we hypothesized that p53 might regulate the promoter activity of the basic FGF gene, which has several GC boxes and no typical TATA box