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CREM — IL2

Text-mined interactions from Literome

Kyttaris et al., J Immunol 2004 (Lupus Erythematosus, Systemic) : Thus, CREM is involved indirectly in the modulation of transcriptional regulation of multiple genes including IL-2
Higai et al., Biochim Biophys Acta 2009 : The prolonged culture in high glucose increased inducible cAMP early repressor (ICER) II mRNA and protein levels, and overexpression of ICER II dose-dependently suppressed promoter activities of IL-2 , NFAT, and AP-1
Koga et al., J Immunol 2012 (Lupus Erythematosus, Systemic...) : The activity of calcium/calmodulin dependent protein kinase IV ( CaMK4 ) is increased in T cells from patients with systemic lupus erythematosus ( SLE ) and has been shown to reduce IL-2 production by promoting the effect of the transcriptional repressor cAMP responsive element modulator-a on the IL2 promoter
Bodor et al., Proc Natl Acad Sci U S A 1996 : Further, in transcriptional assays in vivo, ICER inhibits calcineurin mediated expression of the interleukin 2 promoter as well as Tax mediated transactivation of the human T-lymphotropic virus type I ( HTLV-I ) promoter