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EPHB2 — ITGAV
Text-mined interactions from Literome
Das et al., J Biol Chem 2004
(Breast Neoplasms...) :
Furthermore, OPN induces
alpha(v)beta(3) integrin/EGFR mediated
ERK1/2 phosphorylation and AP-1 activation
Rucci et al., J Cell Sci 2005
(Bone Resorption) :
Engagement of
alphavbeta3 integrin triggered
ERK1/2 phosphorylation, but the underlying molecular mechanism was surprisingly independent of the well known Shc/Ras/Raf-1 cascade, and of phosphorylated MAP/ERK kinase (MEK)1/2, so far the only recognized direct activator of ERK1/2
Scarlett et al., J Endocrinol 2008
(MAP Kinase Signaling System...) :
To establish whether transient
ERK activation via the
integrin alpha(V)beta ( 3 ) cell surface receptor mediated these effects, MG-63 cells were pretreated for 30 min with the specific MAPK kinase inhibitor, U0126 ( 1 microM ), or an anti-integrin alpha(V)beta ( 3 ) -blocking antibody
Pavasant et al., Oral Dis 2008
(MAP Kinase Signaling System) :
The anti-alphavbeta3 integrin antibody could also inhibit ERK activation, suggesting the possible
role of
alphavbeta3 integrin on the regulation of
ERK and cell migration