Fernández-Tome et al., Biochem Biophys Res Commun 2004
:
Our results indicate that PGD ( 2 ) stimulatory effect involves both PLD and ERK1/2-MAPK activation, and both pathways operate independently of PC synthesis homeostasis
Relic et al., J Biol Chem 2006
(Osteoarthritis) :
15d-PGJ2, PGD2 , and partially UO126, down-regulated ERK1/2 phosphorylation, protected cells from BAY 11-7085 induced apoptosis, and reversed both PPAR-gamma dephosphorylation and degradation