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AKT3 — NOTCH1

Text-mined interactions from Literome

Ciofani et al., Nat Immunol 2005 : Furthermore, the trophic effects of Notch signaling were mediated by the pathway of phosphatidylinositol-3-OH kinase and the kinase Akt , such that expression of active Atk overcame the requirement for Notch in beta-selection
Gude et al., Circ Res 2008 (Disease Models, Animal...) : These results indicate Notch activation in cardiomyocytes is mediated through c-Met and Akt survival signaling pathways, and Notch1 signaling in turn enhances Akt activity
Song et al., FEBS Lett 2008 : The effect of Akt on Notch intracellular domain ( NICD ) -mediated transcription was investigated
Bedogni et al., J Clin Invest 2008 (Anoxia...) : Here we show that Notch1 signaling is elevated in human melanoma samples and cell lines and is required for Akt and hypoxia to transform melanocytes in vitro ... Hyperactivated PI3K/Akt signaling led to upregulation of Notch1 through NF-kappaB activity, while the low oxygen content normally found in skin increased mRNA and protein levels of Notch1 via stabilization of HIF-1alpha
Meurette et al., Cancer Res 2009 : Notch activation induces Akt signaling via an autocrine loop to prevent apoptosis in breast epithelial cells
Dong et al., Cancer Res 2010 (Breast Neoplasms) : Expression of the activated form of Notch1 restores AKT activity and enables cells to overcome cell death after dual-pathway blockade
Zhang et al., Cancer Sci 2012 (Glioblastoma...) : In U87MG cells, the activation of Notch1 by DLL4 stimulation or by the overexpression of Notch intracellular domain ( NICD ) resulted in AKT activation and thereby promoted ß-catenin activity and NF-?B signaling ... In U87MG cells, the activation of Notch1 by DLL4 stimulation or by the overexpression of Notch intracellular domain ( NICD ) resulted in AKT activation and thereby promoted ß-catenin activity and NF-?B signaling
Jin et al., Neurosci Lett 2013 (Brain Neoplasms...) : We confirmed that MK-2206 effectively inhibits Akt phosphorylation in a dose dependent manner, whereas MRK003 inhibits Notch signaling and Akt phosphorylation
Guo et al., Mol Cancer Res 2013 (Lung Neoplasms) : Despite the activation of Notch, AKT activation and cell survival were not affected by Notch inhibitors DAPT or compound E
Hales et al., J Biol Chem 2013 (Precursor T-Cell Lymphoblastic Leukemia-Lymphoma) : GSI treatments increased AKT-Thr ( 308 ) phosphorylation and signaling in PTEN-deficient, GSI-resistant T-ALL cell lines ( Jurkat, CCRF-CEM, and MOLT3 ), suggesting that Notch1 represses AKT independent of its PTEN transcriptional effects
Pajvani et al., Nat Med 2013 (Body Weight...) : Acute or chronic inhibition of Notch dampens hepatic glucose production and increases Akt activity and may therefore be predicted to increase hepatic lipid content
Pei et al., Basic Res Cardiol 2013 (Myocardial Reperfusion Injury) : Moreover, Notch1 blockade also reduced phosphorylation of endothelial NO synthase (eNOS) and Akt , and increased expression of PTEN, a key phosphatase involved in the regulation of Akt phosphorylation ... Moreover, Notch1 blockade also reduced phosphorylation of endothelial NO synthase (eNOS) and Akt , and increased expression of PTEN, a key phosphatase involved in the regulation of Akt phosphorylation