◀ Back to RAC1
PXN — RAC1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Gakidis et al., J Cell Biol 2004
:
beta2 induced activation of Cdc42,
Rac1 , and RhoA is defective in Vav1/3ko neutrophils, and phosphorylation of Pyk2,
paxillin , and Akt is also significantly
reduced
Vallés et al., J Biol Chem 2004
:
Activation of
Rac1 by
paxillin-Crk-DOCK180 signaling complex is antagonized by Rap1 in migrating NBT-II cells
Chen et al., Mol Cell Biol 2005
:
Supporting these genetic data, biochemical studies indicate that
paxillin regulates
Rac and Rho activity, positively regulating Rac and negatively regulating Rho
Kobayashi et al., Mol Cell Biol 2006
(Neoplasm Invasiveness...) :
GSK-3 inhibitors suppressed the disassembly of
paxillin and the
activation of FAK and
Rac
Birukova et al., Am J Physiol Lung Cell Mol Physiol 2007
:
Paxillin-beta-catenin interactions are involved in
Rac/Cdc42 mediated endothelial barrier-protective response to oxidized phospholipids
Saito et al., Biol Pharm Bull 2008
(Wounds and Injuries) :
TNIIIA2-treatment unaffected autophosphorylation of focal adhesion kinase ( FAK ), but induced its physical association with phospho-paxillin ( Tyr118 ), suggesting the
FAK/paxillin dependent negative regulation of
Rac activation
Birukova et al., Am J Physiol Lung Cell Mol Physiol 2008
:
Our results demonstrate that OxPAPC induced
Rac dependent , Rho independent peripheral accumulation of paxillin containing FAs and time dependent
paxillin phosphorylation
Nomura et al., Oncol Rep 2008
(Glioblastoma) :
Furthermore, inhibition of
Rac1 reduced phosphorylation of
paxillin , a focal adhesion component and a downstream effector of JNK, at serine 178 ( Ser178 )
Deakin et al., J Cell Sci 2009
:
Although pair-wise interaction between alpha4 integrin and
paxillin is
sufficient for normal
Rac1 regulation, the integrity of the ternary complex is essential for focused Cdc42 activity at the lamellipodial leading edge and directed cell movement
Choi et al., Circ Res 2009
(Chronic Disease...) :
We show that mmLDL induced recruitment of spleen tyrosine kinase (Syk) to a TLR4 signaling complex, TLR4 phosphorylation, activation of a Vav1-Ras-Raf-MEK-ERK1/2 signaling cascade, phosphorylation of
paxillin , and
activation of
Rac , Cdc42, and Rho
Deakin et al., PloS one 2012
:
Paxillin and Hic-5 interaction with vinculin is differentially
regulated by
Rac1 and RhoA ... These data identify discrete
roles for
paxillin and Hic-5 in
Rac1 and RhoA dependent cell adhesion formation and maturation ; processes essential for productive cell migration
Tong et al., Biochim Biophys Acta 2013
:
TG-2 dependent ß-3 integrin activation, serine-phosphorylation of
paxillin , and
Rac and CDC42
activation may thus play a key functional role in enhancing corneal epithelial cell adhesion and migration during wound healing
Hu et al., Cell Signal 2013
(Carcinoma, Hepatocellular...) :
Inhibitor studies revealed that ERK was required for HGF induced paxillin phosphorylation at Ser178, whereas PKC and
Rac-1 may
suppress HGF induced phosphorylation of ERK and
paxillin ( at Ser178 ) and upregulate phosphorylation of paxillin at Tyr31
Hung et al., J Cell Biol 2013
(Melanoma...) :
However, unlike unconfined ( 2D ) migration, which depends on enhanced Rac1 activity achieved by preventing a4/paxillin binding, confined migration requires myosin II-driven contractility, which is increased when
Rac1 is
inhibited by
a4/paxillin binding