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CREB3 — IL6
Text-mined interactions from Literome
Tokunou et al., Arterioscler Thromb Vasc Biol 2001
:
Overexpression of the dominant negative form of
CREB inhibited thrombin induced
IL-6 mRNA expression ... These results suggest that the CRE site and
CREB play an important role in thrombin induced
IL-6 gene expression in VSMCs. Transactivation of EGF-R and activation of ERK and p38 MAPK are involved in this process
Chen et al., J Biol Chem 2004
(MAP Kinase Signaling System) :
Phosphorylation of the transcription factor
CREB was also
necessary but not sufficient for PTHrP mediated
IL-6 promoter activity
Persson et al., Bone 2005
:
These observations, together, demonstrate that VIP stimulates
IL-6 production in osteoblasts by a mechanism likely to be mediated by VPAC2 receptors and
dependent on cyclic AMP/protein kinase
A/CREB activation and also involving the transcription factors C/EBP and AP-1
Hannila et al., Exp Neurol 2008
(Spinal Cord Injuries) :
It is now known that the effects of cAMP are transcription dependent, and that cAMP mediated activation of
CREB leads to upregulated expression of genes such as arginase I and
interleukin-6
Shi et al., J Nutr Biochem 2009
:
These data suggest that DON induced
IL-6 expression is
CREB mediated and PKR dependent, and that requisite kinase activities for these pathways were suppressed in macrophages from mice fed DHA for an extended period
Chan et al., J Pharmacol Exp Ther 2009
(Pancreatitis) :
cAMP-responsive element binding protein ( CREB ) might be
involved in ERK1/2 induced
IL-6 expression because phosphorylation of CREB was observed after angiotensin II treatment, which was reversed by losartan and the ERK1/2 inhibitor
Chava et al., Arterioscler Thromb Vasc Biol 2009
(Carotid Artery Injuries...) :
CREB mediated
IL-6 expression is required for 15 ( S ) -hydroxyeicosatetraenoic acid induced vascular smooth muscle cell migration ... Dominant negative
CREB also
suppressed balloon injury induced
IL-6 expression, SMC migration from media to intimal region, and neointima formation ... The above results suggest a role for 15-LOX2-15-HETE in the regulation of VSMC migration and neointima formation involving
CREB mediated
IL-6 expression
Allen et al., Am J Physiol Regul Integr Comp Physiol 2010
(Calcium Signaling) :
Finally,
CREB and C/EBP were necessary for basal IL-6 promoter activity and
sufficient to increase
IL-6 promoter activity but had minimal roles in calcineurin activated IL-6 promoter activity