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KAT2B — MDM2
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
KAT2B
—
MDM2
(direct interaction, pull down)
Jin et al., J Biol Chem 2002*
-
IRef Biogrid Interaction:
KAT2B
—
MDM2
(physical association, affinity chromatography technology)
Jin et al., J Biol Chem 2002*
-
IRef Biogrid Interaction:
KAT2B
—
MDM2
(direct interaction, enzymatic study)
Jin et al., J Biol Chem 2004*
-
IRef Biogrid Interaction:
KAT2B
—
MDM2
(physical association, affinity chromatography technology)
Jin et al., J Biol Chem 2004*
-
IRef Biogrid Interaction:
KAT2B
—
MDM2
(direct interaction, enzymatic study)
Jung et al., J Clin Invest 2010*
-
IRef Biogrid Interaction:
KAT2B
—
MDM2
(direct interaction, enzymatic study)
Wang et al., J Biol Chem 2011*
-
IRef Hprd Interaction:
KAT2B
—
MDM2
(in vitro)
Jin et al., J Biol Chem 2002*
-
IRef Hprd Interaction:
KAT2B
—
MDM2
(in vivo)
Jin et al., J Biol Chem 2002*
-
IRef Ophid Interaction:
MDM2
—
KAT2B
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Jin et al., J Biol Chem 2002
:
Consistent with the above results,
MDM2 significantly
repressed the activation of p53 transcriptional activity by
PCAF without apparently affecting the level of p53
Jin et al., J Biol Chem 2004
:
Our further study showed that
MDM2 also
regulates the stability of
PCAF ... Restriction of PCAF in the nucleus by leptomycin B did not affect
MDM2 mediated
PCAF degradation ... Consistently, overexpression of
MDM2 in p53 null cells
caused the reduction of the protein level of
PCAF , but not the mRNA level
Kass et al., Cell cycle (Georgetown, Tex.) 2009
:
We found that PCAF interacts with both
Mdm2 and Chk2 and that
PCAF increases Chk2 ubiquitination and degradation