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AKAP13 — RHOA

Pathways - manually collected, often from reviews:

• BioCarta rho-selective guanine exchange factor akap13 mediates stress fiber formation: PKAc/RII-alpha/RII-beta/AKAP13 complex (PRKACB-PRKACG-PRKAG1-PRKAR2A-PRKAR2B-AKAP13) → RhoA (RHOA) (modification, activates)
• NCI Pathway Database Regulation of RhoA activity: AKAP13 (AKAP13) → RHOA/GTP complex (RHOA) (modification, activates) Besson et al., Genes Dev 2004*, Baisamy et al., J Biol Chem 2005*, Glaven et al., J Biol Chem 1996*
  Evidence: assay, physical interaction
• NCI Pathway Database Regulation of RhoA activity: AKAP13 (AKAP13) → RHOA/GDP complex (RHOA) (modification, activates) Besson et al., Genes Dev 2004*, Baisamy et al., J Biol Chem 2005*, Glaven et al., J Biol Chem 1996*
  Evidence: assay, physical interaction
• NCI Pathway Database PAR1-mediated thrombin signaling events: AKAP13 (AKAP13) → RHOA/GTP complex (RHOA) (modification, activates) Gohla et al., J Biol Chem 1999, Majumdar et al., J Biol Chem 1999*
  Evidence: mutant phenotype, assay
• NCI Pathway Database PAR1-mediated thrombin signaling events: AKAP13 (AKAP13) → RHOA/GDP complex (RHOA) (modification, activates) Gohla et al., J Biol Chem 1999, Majumdar et al., J Biol Chem 1999*
  Evidence: mutant phenotype, assay
• Reactome Reaction: RHOA → AKAP13 (reaction) Reid et al., J Biol Chem 1999, Schmidt et al., Genes Dev 2002, Jaffe et al., Annu Rev Cell Dev Biol 2005, Ramos-Morales et al., Oncogene 1995, Pasteris et al., Cell 1994, Hart et al., J Biol Chem 1994, Hart et al., J Biol Chem 1996, Zheng et al., J Biol Chem 1996, Van Aelst et al., Genes Dev 1997, Ren et al., J Biol Chem 1998

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: RHOA — AKAP13 (physical association, affinity chromatography technology) Klussmann et al., FEBS Lett 2001*
• IRef Hprd Interaction: RHOA — AKAP13 (in vivo) Klussmann et al., FEBS Lett 2001*, Tan et al., Anal Biochem 2002*
• IRef Ophid Interaction: RHOA — AKAP13 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: RHOA — AKAP13 (aggregation, confirmational text mining) Klussmann et al., FEBS Lett 2001*

Text-mined interactions from Literome

Dutt et al., Cell Signal 2004 : proto-Lbc mutant expression also led to decreased levels of Galpha12 induced RhoA activation in vivo
Appert-Collin et al., Proc Natl Acad Sci U S A 2007 (Hypertrophy) : In particular, our results indicate that suppression of AKAP-Lbc expression by infecting rat neonatal ventricular cardiomyocytes with lentiviruses encoding AKAP-Lbc-specific short hairpin RNAs strongly reduces both alpha1-AR mediated RhoA activation and hypertrophic responses
O'Connor et al., Am J Physiol Cell Physiol 2012 : Integrin a6ß4 cooperates with LPA signaling to stimulate Rac through AKAP-Lbc mediated RhoA activation ... Notably, the activation of RhoA by cooperative LPA and integrin a ( 6 ) ß ( 4 ) signaling requires the Rho guanine nucleotide exchange factor AKAP-Lbc