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RHOA — SMURF2

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: SMURF2 — RHOA (direct interaction, enzymatic study) Lu et al., J Biol Chem 2011*
• IRef Biogrid Interaction: SMURF2 — RHOA (direct interaction, pull down) Ogunjimi et al., J Biol Chem 2010*
• IRef Intact Interaction: Complex of RHOA-UBB-SMURF2 (enzymatic reaction, enzymatic study) Wiesner et al., Cell 2007

Text-mined interactions from Literome

Bryan et al., FEBS Lett 2005 : Interestingly, Smurf1 overexpression in Neuro2a cells dramatically reduces RhoA protein levels during dibutyric cyclic AMP, but not retinoic acid induced neurite outgrowth
Ogunjimi et al., J Biol Chem 2010 : Analysis of mutants of the HECT UBS reveal that interfering with the UBS surface blocked Smurf dependent degradation of its substrate RhoA in cells