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IFNG — IL16
Text-mined interactions from Literome
Lalain et al., Diabetologia 1999
(Diabetes Mellitus, Type 1) :
During proliferation in response to islet cells,
interleukin-10 increased 43-fold ( p < 0.01 ) but
interferon-gamma increased only slightly
Filice et al., Infect Immun 1999
(Cytomegalovirus Infections...) :
As pulmonary inflammation developed, levels of cytokine mRNAs for gamma interferon ( IFN-gamma ),
interleukin-2 (IL-2), IL-4, and IL-10 increased in bronchoalveolar lavage (BAL) cells or lung tissue, and the level of
IFN-gamma protein
increased in BAL fluid
Sugaya et al., J Invest Dermatol 1999
:
Interleukin-18 or
interleukin-12 alone did not
induce interferon-gamma production by dendritic epidermal T cells ... Thus, this study suggests that interleukin-18 and
interleukin-12 produced by keratinocytes and Langerhans cells
regulate interferon-gamma production by dendritic epidermal T cells and thus may play important parts in the regulation of immune responses in skin associated lymphoid tissues
Elhofy et al., Infect Immun 1999
(Salmonella Infections, Animal) :
It has recently been suggested that,
interleukin-18 (IL-18), in addition to IL-12,
contributes to the induction of
IFN-gamma following infection
Dybing et al., Infect Immun 1999
(Salmonella Infections, Animal) :
As such, several different cytokines including,
interleukin-12 (IL-12) and IL-18, can
induce IFN-gamma
Francis et al., Immunology 2000
(Arthritis, Experimental...) :
Peptide inhalation
induces the production of Th1-type cytokines (
interferon-gamma ) whereas intraperitoneal immunization leads to the production of Th2-type cytokines ( interleukin-4,
interleukin-5 and interleukin-10 ) by splenic T cells upon stimulation with peptide
Koh et al., J Clin Immunol 2001
(Asthma...) :
As a correlate,
interleukin-4 (IL-4) production significantly decreased and
interferon-gamma (IFN-gamma) slightly
increased , resulting in a markedly decreased ratio of IL-4-IFN-gamma in OVA presensitized rats with BCG infection
Kitagawa et al., J Rheumatol 2001
(Arthritis, Rheumatoid) :
Interferon-gamma enhances
interleukin 12 production in rheumatoid synovial cells via CD40-CD154 dependent and independent pathways
Sutherland et al., Immunol Rev 2001
:
Although ULBPs alone activate multiple signaling pathways and induce modest cytokine production, ULBPs
synergize strongly with
interleukin-12 for production of
interferon-gamma by NK cells
Puliti et al., Arthritis Rheum 2002
(Arthritis, Infectious...) :
The beneficial effect of
interleukin-12 on arthritis induced by group B streptococci is
mediated by
interferon-gamma and interleukin-10 production
De Bie et al., Clin Exp Allergy 2002
(Asthma...) :
Thirdly, the presence of
IL-16 during priming cultures of TCR transgenic T cells ( DO11.10 ),
reduces IL-4 ( 33 % ) and IL-5 ( 35 % ), but not IL-10 and
IFNgamma levels upon re-stimulation
Malmgaard et al., J Gen Virol 2003
(Herpes Simplex) :
Interferon (IFN)-alpha/beta,
interleukin (IL)-12 and IL-18 coordinately
induce production of
IFN-gamma during infection with herpes simplex virus type 2
Tomoda et al., Biochim Biophys Acta 1992
(Leukemia, Monocytic, Acute) :
Inhibition of
interferon-gamma- and phorbol ester
induced HLA-DR and
interleukin-1 production by the expression of a transfected poly ( ADP-ribose ) synthetase gene in human leukemia THP-1 cells
Imanishi et al., Hepatogastroenterology 2003
(Carcinoma, Hepatocellular...) :
We evaluated
interleukin-12 induced
interferon-gamma production as one of the immunological markers of patients with chronic liver diseases ... The level of
interleukin-12 induced
interferon-gamma production by peripheral blood mononuclear cells in the patients with hepatocellular carcinoma was significantly lower than that in the patients with liver cirrhosis which is thought to be a premalignant state
Murray et al., Infect Immun 2003
(Leishmaniasis, Visceral) :
Optimal killing triggered by both anti-CD40 and anti-CTLA-4 required endogenous
IFN-gamma and
involved interleukin 12
dos Santos et al., Vet Immunol Immunopathol 2004
(Dog Diseases...) :
Recombinant single-chain canine
interleukin 12
induces interferon gamma mRNA expression in peripheral blood mononuclear cells of dogs with visceral leishmaniasis
Ethuin et al., Lab Invest 2004
:
Human neutrophils produce
interferon gamma upon
stimulation by
interleukin-12
Loughlin et al., Immunology 1992
:
Regulation of Fc receptor and major histocompatibility complex antigen expression on isolated rat microglia by tumour necrosis factor,
interleukin-1 and lipopolysaccharide :
effects on
interferon-gamma induced activation
Fernández-Lago et al., J Med Microbiol 2005
(Brucellosis) :
Following infection,
interleukin-18 (IL-18) may
contribute , in association with IL-12, to optimal
IFN-gamma production
Ellermann-Eriksen et al., Virology journal 2005
(Herpes Simplex) :
In the next wave,
interleukin (IL)-12 together with the above and other cytokines
induce production of
IFN-gamma in mainly NK cells
Wood et al., Eur J Pediatr 2005
(Hypersensitivity) :
Defects in
interferon-gamma receptor/interleukin-12 receptor
responses are not sufficient to cause clinical allergic disease
Rezende et al., Int Endod J 2005
:
The cellular viability and the production of tumour necrosis factor-alpha,
interleukin (IL)-12 and IL-10 in
response to stimulation with
interferon-gamma and Fusobacterium nucleatum or Peptostreptococcus anaerobius were evaluated
El Bassam et al., Immunology 2006
(Asthma...) :
To evaluate whether the modulatory effect of
IL-16 on cytokine synthesis was
mediated by
interferon-gamma (IFN-gamma) , IL-10, IL-12 or IL-18, allergen stimulated PBMC were cultured in presence of IL-16 and neutralizing concentrations of relevant antibodies
Kriegel et al., Immunology 2006
:
Interleukin-4 supports
interleukin-12 induced proliferation and
interferon-gamma secretion in human activated lymphoblasts and T helper type 1 cells
Al-Attiyah et al., Clin Exp Immunol 2006
(Tuberculosis) :
Among the cytokines studied,
interleukin (IL)-10 and IL-12 were not
detected at all, whereas low levels of
interferon (IFN)-gamma after 96 h ( 0.4 IU/ml ) and tumour necrosis factor (TNF)-alpha after 48 ( 135 pg/ml ) and 96 h ( 47 pg/ml ) of culture were detected in the supernatants of whole blood infected with M. tuberculosis
Price et al., Immunology 2007
:
Workshop cluster 1+ gammadelta T-cell receptor T cells from calves express high levels of
interferon-gamma in
response to stimulation with
interleukin-12 and -18
Ghiringhelli et al., Immunol Rev 2006
(Disease Progression...) :
This review summarizes the findings showing that Tregs suppress NK cell effector functions in vitro and in vivo, i.e. homeostatic proliferation, cytotoxicity, and
interleukin-12 mediated
IFN-gamma production
Trudelle et al., Int Arch Allergy Immunol 2007
:
To evaluate whether the modulatory effect of
IL-16 on IgE production was
mediated by
interferon-gamma (IFN-gamma) , anti-CD40/IL-4 stimulated PBMC were cultured in the presence of rIL-16 and neutralizing concentrations of anti-IFN-gamma antibody
Tsuda et al., Cancer Res 2007
(Ovarian Neoplasms) :
RNAs in ISMMC stimulate immature dendritic cells to secrete
interleukin 12 and
induce IFN-gamma in peripheral blood mononuclear cells
Cho et al., Exp Mol Med 2008
(Arthritis, Rheumatoid) :
Moreover, mRNA expression of
IL-16 by RA-FLS
increased after treatment with IL-17 but not with IL-15, IL-1beta, and
IFN-gamma
Ebert et al., Immunology 2008
:
Massive
interleukin-12 induced
interferon-gamma production by interleukin-15 stimulated lamina propria lymphocytes followed by down-regulation of the interleukin-12 receptor
Lonial et al., Exp Hematol 2008
:
The immunostimulatory effect of DC1 required DC-to-T-cell contact, and
induced interleukin-12 secretion, while DC2 cells induced
interferon-gamma secretion
Kubera et al., J Pharmacol Sci 2008
(Cocaine-Related Disorders...) :
Cocaine self administered for 18 days
induced a significant increase in spleen weight, plasma corticosterone levels,
interleukin (IL)-10 , and tumor necrosis factor-alpha production, while concanavalin A-stimulated proliferation responses of peripheral blood T-lymphocytes and
interferon-gamma production by splenic lymphocytes were not altered
Campos Alberto et al., Immunology 2009
:
Differential effects of tumour necrosis factor-alpha and
interleukin-12 on isopentenyl pyrophosphate
stimulated interferon-gamma production by cord blood Vgamma9 T cells
Vesosky et al., Infect Immun 2009
(Tuberculosis) :
In addition, M. tuberculosis induced
IFN-gamma production by CD8 T cells isolated from naïve old mice was major histocompatibility complex class I independent but was
dependent on
interleukin-12p70 , confirming an innate role of CD8 T cells during M. tuberculosis infection
Bill et al., Mol Cancer Ther 2009
(Melanoma) :
Finally, stimulation of natural killer ( NK ) cells with curcumin reduced the level of
interleukin-12 induced
IFN-gamma secretion, and production of granzyme b or IFN-gamma upon coculture with A375 melanoma cells or NK-sensitive K562 cells as targets
Armstrong-James et al., J Infect Dis 2009
(Pulmonary Aspergillosis) :
Impaired
interferon-gamma responses,
increased interleukin-17 expression, and a tumor necrosis factor-alpha transcriptional program in invasive aspergillosis
Beldi et al., Hepatology 2010
(Reperfusion Injury) :
Specifically, ATPgammaS ( a nonhydrolyzable ATP analog ) inhibits secretion of
interferon gamma by NK cells in
response to
interleukin-12 and interleukin-18, providing a mechanistic link between CD39 deletion and altered cytokine secretion
Reiner et al., J Clin Invest 1990
(Leishmaniasis, Visceral) :
Interferon-gamma prevents parasite induced inhibition of
interleukin 1 production and primes monocytes to respond to Leishmania by producing both tumor necrosis factor-alpha and interleukin 1
Xie et al., Int J Oncol 1993
:
L929 parental cells and L929 cells selected for resistance to tumor necrosis factor ( TNF-alpha ) were incubated in vitro with various concentrations of TNF-alpha,
interleukin-1 , and lipopolysaccharide (LPS) in the
presence or absence of mouse
interferon-gamma (IFN-gamma)
Miossec et al., J Immunol 1986
:
Immune interferon enhances the production of
interleukin 1 by human endothelial cells stimulated with lipopolysaccharide
Gerrard et al., J Immunol 1987
:
Differential
effects of interferon-alpha and
interferon-gamma on
interleukin 1 secretion by monocytes
Haq et al., Immunobiology 1988
:
Failure of hydrocortisone to suppress the
interferon-gamma induced augmentation of
interleukin 1 secretion of aged human monocytes
Auböck et al., Arch Dermatol Res 1985
:
HLA-DR expression was
induced by the supernatants and human recombinant
interferon-gamma ( rIFN-gamma ), whereas recombinant interferon-alpha 2,
interleukin-2 and non-recombinant human interferon-beta had no such effect
Hunter et al., Eur J Immunol 1995
(Toxoplasmosis, Animal) :
Transforming growth factor-beta inhibits
interleukin-12 induced production of
interferon-gamma by natural killer cells : a role for transforming growth factor-beta in the regulation of T cell independent resistance to Toxoplasma gondii
Ogata et al., Br J Haematol 1995
(Myelodysplastic Syndromes) :
Effects of
interleukin-12 on natural killer cell cytotoxicity and the production of
interferon-gamma and tumour necrosis factor-alpha in patients with myelodysplastic syndromes
Nakamura et al., Infect Immun 1993
:
The factor,
interleukin-2 , anti-CD3 MAb, or ConA alone
induced a trace of or no detectable
IFN-gamma in these cells
Sanchez-Bueno et al., Biochem Biophys Res Commun 1996
(Fibrosarcoma) :
Interferon-gamma dependent expression of inducible nitric oxide synthase,
interleukin-12 , and interferon-gamma inducing factor in macrophages elicited by allografted tumor cells
Libraty et al., J Clin Invest 1997
(Leprosy) :
Interferon-gamma differentially
regulates interleukin-12 and interleukin-10 production in leprosy
Trinchieri et al., Curr Opin Hematol 1997
:
If interleukin-12 and
interleukin-12 induced
interferon gamma are present during early T-cell expansion in response to antigen, T-helper type-1 cell generation is favored and generation of T-helper type-2 cells is inhibited
Gollob et al., Eur J Immunol 1997
:
Interferon-gamma and interleukin-4
regulate T cell
interleukin-12 responsiveness through the differential modulation of high-affinity interleukin-12 receptor expression
Hunter et al., Eur J Immunol 1997
:
Comparison of the
effects of interleukin-1 alpha,
interleukin-1 beta and interferon-gamma inducing factor on the production of
interferon-gamma by natural killer
Gross et al., Infect Immun 1998
:
Expression of iNOS,
interleukin-6 , and tumor necrosis factor alpha (TNF-alpha) mRNAs was induced in both c-Brucella- and ops-Brucella infected cells and was strongly
potentiated by
IFN-gamma
Hayes et al., Blood 1998
(Cell Transformation, Viral) :
Interferon-gamma dependent
inducible expression of the human
interleukin-12 p35 gene in monocytes initiates from a TATA containing promoter distinct from the CpG-rich promoter active in Epstein-Barr virus transformed lymphoblastoid cells
Baden et al., J Biol Chem 1998
:
The amino-terminal domain of STAT4 ( STAT4 ( 1-124 ) ) is required for cooperative binding interactions between STAT4 dimers and activation of
interferon-gamma transcription in
response to
interleukin-12
Fulton et al., J Infect Dis 1998
:
Regulation of
interleukin-12 by interleukin-10, transforming growth factor-beta, tumor necrosis factor-alpha, and
interferon-gamma in human monocytes infected with Mycobacterium tuberculosis H37Ra
Byl et al., J Interferon Cytokine Res 1998
(Acquired Immunodeficiency Syndrome) :
Bacterial extract OM85-BV induces
interleukin-12 dependent
IFN-gamma production by human CD4+ T cells
Hodge-Dufour et al., Proc Natl Acad Sci U S A 1998
(Inflammation) :
Inhibition of
interferon gamma induced
interleukin 12 production : a potential mechanism for the anti-inflammatory activities of tumor necrosis factor