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IFNG — SOD1
Text-mined interactions from Literome
Maehara et al., FEBS Lett 1999
:
Cooperative interaction of NF-kappaB and C/EBP binding sites is necessary for manganese
superoxide dismutase gene transcription
mediated by lipopolysaccharide and
interferon-gamma ... This report provides the first evidence that cooperation between two distinct cis acting elements may be required for induction of
Mn-SOD gene expression
mediated by lipopolysaccharide and
interferon-gamma
StrĂ¥lin et al., Atherosclerosis 2000
:
The
Mn-SOD activity was strongly
up-regulated by TNF-alpha and IL-1alpha and moderately by
IFN-gamma
Piganelli et al., Diabetes 2002
(Diabetes Mellitus, Experimental...) :
We found that the
SOD mimic significantly
inhibited antigen presenting cell dependent T-cell proliferation and
IFN-gamma production in vitro
Ono et al., Biochem Biophys Res Commun 1992
(Carcinoma, Hepatocellular...) :
Effects of Tumor Necrosis Factor (TNF), Interleukin-1 (IL-1), Interleukin-6 (IL-6) and
Interferon-gamma (IFN-gamma) on the expression of
Mn-superoxide dismutase ( Mn-SOD ) protein were investigated in human hepatoma cells, Hu-H1, which revealed resistance to the cytotoxicity of TNF and IL-1
Marklund et al., J Biol Chem 1992
:
TNF-alpha, IL-1 alpha, and
IFN-gamma stimulated the
Mn-SOD activity, as previously known, and these responses were reduced by TGF-beta
Bian et al., Zhonghua Nan Ke Xue 2007
:
TNF-alpha showed stronger inhibiting effect,
IFN-gamma markedly
reduced the activities of Na+ -K+ -ATPase, Ca2+ -ATPase and
SOD in sperm ( P < 0.01 ), and their synergistic action was weaker
Harris et al., J Immunol 1991
:
Manganese
superoxide dismutase is
induced by
IFN-gamma in multiple cell types ...
Mn-SOD is
induced by
IFN-gamma and also by TNF in all four human cell lines examined : HS153 fibroblasts, ACHN renal carcinoma, A549 lung carcinoma, and A375 melanoma ... The
induction of
Mn-SOD by IFN-gamma and its synergistic induction by
IFN-gamma in combination with TNF and IL-1 should protect healthy cells from the toxicity of O2- during an immune response, and may provide a mechanism for selective killing of infected cells
Stefanova et al., Z Naturforsch C 2010
(Arthritis, Experimental...) :
Yeast
SOD treatment effectively suppressed the spontaneous and recombinant mouse
IFN-gamma + LPS
induced release of NO as well
Dobashi et al., J Neurochem 1997
:
In spite of the stimulation of mRNA level, LPS and
IFN-gamma significantly
inhibited the activity of
Mn-SOD within the first 24 h of incubation ; however, Mn-SOD activity gradually increased with the increase in time of incubation
Sano et al., Immunology 1997
:
IFN-gamma induces expression of inducible NO synthase (iNOS), manganese
superoxide dismutase ( Mn-SOD ) and copper zinc SOD ( CuZn-SOD ) in these cells
Takahashi et al., J Dermatol Sci 1998
:
Interferon-gamma dependent induction of manganese
superoxide dismutase activity of SV40 transformed human keratinocytes by anti-Fas antibody and by TNF-alpha ... The induction of
IFN-gamma dependent
Mn-SOD activity by anti-Fas antibody or TNF-alpha was concentration dependent ; the maximal effect was observed at 1-10 micrograms/ml and 5-10 ng/ml, respectively ... Although the addition of 12-o-tetradecanoylphorbol-13-acetate ( TPA ) singly to the incubation medium had no effect on either Mn-, or Cu, Zn-SOD activity, it significantly augmented the
IFN-gamma dependent induction of
Mn-SOD activity by anti-Fas antibody or by TNF-alpha ... These results indicate that the stimulation of Fas antigen or TNF receptor increases
Mn-SOD activity of SVHK cells in the
presence of
IFN-gamma and that TPA augments the process through the activation of protein kinase C
Habelhah et al., Hokkaido Igaku Zasshi 1998
(Disease Progression...) :
In vitro experiments proved that although
IFN-gamma did not
increase the production of
Mn-SOD by itself, concomitant treatment with both IFN-gamma and TNF-alpha enhanced the Mn-SOD production in QR-32 cells greatly