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Text-mined interactions from Literome

Konishi et al., Cancer Res 2007 (Carcinoma, Non-Small-Cell Lung...) : In this study, we determined the ability of MRK-003 , a gamma-secretase inhibitor, to inhibit Notch3 signaling, growth, and apoptosis of lung cancer cell lines in vitro and in vivo using mouse xenograft models ... We also found that MRK-003 inhibited Notch3 signaling, reduced tumor cell proliferation, inhibited serum independence, and induced apoptosis
Cook et al., J Exp Med 2012 (Anoxia...) : We demonstrate that the gamma secretase inhibitor MRK003 effectively inhibits intratumoral Notch signaling in the KPC mouse model of advanced PDA