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LPA — MMP13
Text-mined interactions from Literome
Fishman et al., Cancer Res 2001
(Neoplasm Invasiveness...) :
In the current study, the
effect of
LPA on
MMP expression and invasive activity was investigated
Zhao et al., J Biol Chem 2006
:
Overexpression of dominant negative PKCdelta or pretreatment with a PKCdelta inhibitor ( rottlerin ) or Src kinase family inhibitor ( PP2 ) partially blocked
LPA induced
MMP activation, proHB-EGF shedding, and EGFR tyrosine phosphorylation ... Down-regulation of Lyn kinase, but not Src kinase, by specific small interfering RNA mitigated
LPA induced
MMP activation, proHB-EGF shedding, and EGFR phosphorylation
Wang et al., Gynecol Oncol 2011
(Neoplasm Invasiveness...) :
Furthermore,
MMP-1 and PAR1 were both significantly
induced by
LPA ( 20 µM ), and siRNA silencing of MMP-1 and PAR1 both significantly reduced LPA 's invasion promoting effect in DOV13 cells ( p < 0.05 )
Komachi et al., Cancer Sci 2012
(Ascites...) :
Ki16198 inhibited LPA induced migration and invasion in several pancreatic cancer cells in vitro, which was associated with the inhibition of
LPA induced
MMP production